카페검색 본문
카페글 본문
-
Neutrophils: mediating TelOxidation and senescence 2022.10.15해당카페글 미리보기
On the other hand, the telomere state controls mitochondrial function and ROS production. Telomere dysfunction activates p53, which binds and represses the promoters of mitochondrial biogenesis factors, leading to mitochondrial...
-
Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
like behavior in 6-OHDA-treated mice (Masini et al. 2018). Another agent enhancing autophagy is resveratrol, which activates the AMPK/SIRT1 pathway. In a PC12 cell line overexpressing mutant α-syn, resveratrol treatment leads to...
-
Re: The metabolic roots of senescence: mechanisms and opportunities for int 2022.09.30해당카페글 미리보기
plaques as well as plaque instability. In the liver, senescent cells can promote steatosis. The SASP also activates macrophages, which elevate CD38 and lower tissue NAD+ evels. In the pancreas, senescent β-cells promote hyperinsulinemia...
-
의회, 의료 대책에 관한 비상 체제에 관한 법률 채택 2022.10.24해당카페글 미리보기
adopt a new EU law which facilitates the timely purchase of and access to medicines, vaccines and raw materials, activates emergency funding and enables the monitoring of production facilities when another health crisis hits. www...
-
Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Disea 2022.10.02해당카페글 미리보기
is the MOTS-c peptide that is derived from an open reading frame in the mitochondrial 12S rRNA-c gene (169). MOTS-c activates AMPK and regulates nuclear gene expression in response to metabolic stress (170). These mechanisms by which...
-
Re: Targeting the molecular & cellular pillars of human aging with exercise 2022.10.08해당카페글 미리보기
aging [[25, 26]]. Telomere shortening increases susceptibility to rampant chromosomal end fusions and activates a prolonged DNA damage response, leading to the induction of cell senescence [[18]]. Many current aging research focus on...
-
Age-related alterations and senescence of mesenchymal stromal cells 2022.10.08해당카페글 미리보기
fate switch of bone MSCs. Bmncr maintains the expression of the extracellular matrix protein fibromodulin, and activates the BMP2 pathway. Restoring Bmncr levels in human bone-marrow MSCs reversed the age-related switch between...
-
Re: Re:Re: 미토콘드리아 기능부전 운동- 알츠하이머를 치료하는 방법 2022.09.21해당카페글 미리보기
Consequently, these events activate PGC-1α, thus allowing its translocation to the nucleus where it co-activates NRF2 to up-regulate the expression of TFAM. Aging causes some areas of the mitochondrial network to be dysfunctional...
-
Re: 자가포식-리소좀 시스템 2020 nature 논문 . 2024.07.10해당카페글 미리보기
and ALR initiation is not known but may be the phosphorylation of UVRAG by reactivated mTOR. Phosphorylated UVRAG activates the class III PI 3-kinase VPS34 to generate PI3P on autolysosomes, whose levels may determine rate of tubulation...
-
β-Hydroxybutyrate - 꼭 읽어야!! 2022.09.22해당카페글 미리보기
production, and downstream inhibition of NF-κB activation (reviewed in Reference 96). More specifically, HCAR activates a neuroprotective subset of macrophages via the production of PGD2 by COX1 (103). The neuroprotective effect of...