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Re:Re:노화와 암에서 텔로미어와 텔로머라제의 역할 - 리뷰논문 2020.02.17해당카페글 미리보기
is detected in approximately 85% to 90% of all malignant tumors (2, 3), making it a highly attractive target for the development of more precision mechanism-based cancer therapeutics. The hope is that such therapies may have minimal or...
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Re: The sirtuin class of histone deacetylases: Regulation and roles in lipi 2020.11.09해당카페글 미리보기
authors detected reduced hepatic expression of known LXR target genes such as Abca1, Srebp1c and of the lipogenic enzyme fatty acid synthase (Fas), regulated by SREBP‐1c. Consistent with the role of SIRT1 in LXR activation demonstrated...
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Re: 아연결핍이 야기하는 12가지 미네랄, 미량 미네랄의 항상성에 미치는 영향 - 2019 쥐 실험 2020.06.28해당카페글 미리보기
have not been reported for conditions of zinc deficiency. Likewise, there is no study of zinc-deficient animals or humans for which measurements of minerals and trace elements have been performed concurrently in serum, urine, feces, and...
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Re:Mitochondrial metabolism and cancer - 2017 nature review 2020.01.16해당카페글 미리보기
promising target for the development of novel antineoplastic agents, and several venues are currently being explored in this sense25,26. One of the main problems with targeting mitochondria as a strategy to kill malignant cells or...
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Re: 비타민 D는 섬유아세포의 과도한 콜라겐합성을 억제하여 섬유화를 방지 2020.09.18해당카페글 미리보기
osteogenesis target genes were applied in triplicates in order to confirm the GE Array data. Aliquots of total cellular RNA isolated with Trizol-Reagent from C3H 10T1/2 cells undergoing differentiation with AZCT were treated with or...
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Re: Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythe 2021.03.29해당카페글 미리보기
was detected when subjects were treated with excessive proteins (46). It has also been postulated that not only proteins but also selected amino acids may influence the course of SLE. In a case-controlled study, levels of serum L...
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히스톤 메틸화 - dynamic mark in health, disaease, inheritance(유전) 2020.09.12해당카페글 미리보기
frequent target of chromosomal translocations in acute myeloid leukemia (AML), acute lymphoblastic leukaemia (ALL) or mixed lineage leukaemia (MLL). It is unclear whether it is the misregulation of the methyltransferase activity of MLL1...
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Re: 비타민 D의 항암효과 Nature 논문 2020.02.01해당카페글 미리보기
therapeutic target152,153,154. In contrast to the positive association in those cancer types, some conflicting data have been reported for prostate cancer146,155 and even an inverse correlation between CYP24A1 expression and tumor...
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Re:Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities 2020.02.02해당카페글 미리보기
are detected in the early stages of colorectal cancer, but their expression decreases as the disease progresses (8). Third, the tumor microenvironment (TME) remains a major barrier to the effectiveness of adoptively transferred NK cells...
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Re: 메벤다졸의 항암효과 - 2019년 cancers 리뷰논문 2020.10.09해당카페글 미리보기
is not determined only by intrinsic neoplastic cells features, but is also controlled by interaction with the tumor micro-environment: cancer-associated fibroblasts are responsible for paracrine secretion of growth factors [6...