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Re:Re:Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway 2019.12.15해당카페글 미리보기
and maintenance of DNA methylation patterns requires the function of several DNA methyltransferases (DNMTs), which catalyze DNA methylation reactions, including DNMT1, which maintains methylation, and DNMT3a and DNMT3b, which catalyze de...
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Re: bacterial endotoxin - LPS(lipopolysaccharide)에 대하여 2020.03.30해당카페글 미리보기
be isolated in mg quantities using ArnA (116). In contrast to the proposal of Baker et al. (371), a separate enzyme to catalyze the decarboxylation step is not necessary in our scheme (97, 116). ArnB (previously Orf1 or PmrH) (97, 99...
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Re: 철 대사와 암 2020.01.05해당카페글 미리보기
in Cancer 3.1. Iron Plays an Important Role in Cancer Epigenetics When exist in redox-active form, iron can catalyze Fenton-type reactions and produce highly reactive free radicals, able to oxidize and attack most cellular components [46...
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Re:It’s Getting Hot in Here: Targeting Cancer Stem-like Cells with Hyperthermia 2020.01.29해당카페글 미리보기
temozolomide and doxorubicin [97]. CSCs can also epigenetically silence the enzymes that are needed to catalyze prodrugs into their active forms [97]. Additionally, CSCs can augment pro-survival signaling pathways, including upregulating...
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Re: Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation - 논문 읽어야!! 2019.11.30해당카페글 미리보기
which are catalyzed by enzymes predominantly or exclusively expressed in the liver. Intriguingly, the enzymes that catalyze the individual biosynthetic steps are localized in different cellular compartments, i.e., endoplasmic reticulum...
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Re:Alpha-Ketoglutarate: Physiological Functions and Applications 2020.09.18해당카페글 미리보기
1. First, AKG is a cofactor of prolyl-4-hydroxylase (P4H). P4H is located within the endoplasmic reticulum (ER), and catalyze the formation of 4-hydroxyproline, which is crucial for the formation of the collagen triple helix. Incomplete...
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Re:Re:Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm 2020.06.03해당카페글 미리보기
a mitochondrial outer membrane that involves the recruitment of DRP1 from the cytosol to the mitochondrial surface to catalyze the fission reaction. Notably, it has been demonstrated that mitochondrial stress induced MFF phosphorylation...
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Re:Re:Re: zinc 아연의 항산화 메커니즘 2020.07.04해당카페글 미리보기
of zinc to compete with iron and copper in the binding sites present in the cell membrane. Iron and copper ions can catalyze the production of radicals from lipid peroxides. In this way, the replacement of iron and copper by zinc could...
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Re:Use the protonmotive force: mitochondrial uncoupling and reactive oxygen species 2020.02.15해당카페글 미리보기
of ATP, the energy currency in most cells. The discovery that the mitochondrial ATP synthase uses the pmf to catalyze phosphorylation of ADP confirmed the theory, and in 1978 Mitchell was awarded the Nobel Prize for Chemistry...
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Why US and China need to resolve their innovation dilemma 2018.09.26해당카페글 미리보기
management, new energy and logistics. 3. Success hinges on strategy, implementation and effective governance to catalyze the creative spark of entrepreneurs and innovators; China’s two high-profile industrial polices, Made in China 2025...