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Re: Regulation and function of AMPK in physiology and diseases 2020.11.08해당카페글 미리보기
1c), a transcription factor that promotes the expression of multiple lipogenic enzymes, including ACC1 and FA synthase.49, 50 Excessive accumulation of FAs in cells are stored as TGs. The first committed step in TG synthesis is catalyzed...
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Re:Mitochondrial Homeostasis and Cellular Senescence(세포 노화) 2020.01.17해당카페글 미리보기
metabolic cell status [145,149,150]. In mammalian cells, mitochondrial fusion is primarily orchestrated by large dynamin-related GTPases termed mitofusin 1 (MFN1) and mitofusin 2 (MFN2), plus optic atrophy protein 1 (OPA1) [151,152...
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Re: 인슐린 저항성과 염증에 대하여 2019.09.07해당카페글 미리보기
the c-Jun component of the AP-1 transcription factor, but to date there are no known links between this well-established transcriptional pathway and JNK-induced insulin resistance. Instead, JNK has been shown to promote insulin...
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활성산소의 양을 측정하는 검사(ORP, Oxidation reduction potential) 2020.01.29해당카페글 미리보기
oocyte fusion [9,10]. However, excess ROS results in lipid peroxidation, DNA damage, and induction of apoptosis, all of which trigger a vicious cycle of OS [11]. Clinically, OS can translate into reduced fertilization rates, failure of...
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Re:Re: 암세포 증식을 막는 기전에 관한 nature review 논문 2019.12.29해당카페글 미리보기
data. c Model example in PDAC alterations of coactivators and corepressors and candidate small molecules that can be used as corepressor therapy. d Model schematic summary for p-53 independent differentiation-restoring therapy. Non...
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Re: 암(미토콘드리아 기능부전)과 저산소의 관계에 대한 논문 - 꼭 읽어야 2019.12.25해당카페글 미리보기
hypoxia. C HIGD1A promotes fusion: When the HIF-induced protein HIGD1A targets Opa1, it is protected from cleavage, promotes the interaction with Mfn1 and thus, fusion [50]. Logically, a loss of HIGD1A increases fission, cristae...
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extrachromosomal circular DNA in cancer pathogenesis and therapeutic resist 2020.11.08해당카페글 미리보기
Myc-containing DMs. Moreover, different sizes and architectures of c-Myc amplicons can coexist within the same cell population, providing evidence of DM heterogeneity. Intriguingly, several fusion genes or circular RNA of plasmacytoma...
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Re:Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation 2020.05.28해당카페글 미리보기
Type C SAPs sphingolipid activator proteins (Sap A–D and GM2-AP) Sap saposin A–D Keywords Lysosome Glycosphingolipid Sphingolipid activator protein 1. Lysosomal membrane digestion Lysosomes are major degradative compartments of...
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Re: Re: 오메가 3지방산의 ER stress 반응으로 인한 인슐린 저항성, 미토콘드리아 기능회복에 관한 논문 2020.08.22해당카페글 미리보기
mitochondrial fusion to amelioration of energy cellular metabolism. Moreover, complex interaction between mitochondrial function and dynamics and insulin resistance have been proposed. Therefore, it is auspicious that future studies...
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Re: A Reappraisal of Thymosin Alpha1 in Cancer Therapy - 2019 리뷰 2020.10.10해당카페글 미리보기
1–thymopentin fusion peptide, in combination with Cy, reduced tumor weight more efficiently than Cy and Tα1, with or...Finally, the addition of an RGDR or iRGD motif at the C-terminus to favor tumor homing and cell internalization, or...