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Re:메트포민의 항암 기전 - 2018년 리뷰논문 2020.10.09해당카페글 미리보기
tricarboxylic acid cycle (TCA) activity and metabolites (35, 41–45) and leads to decreased cellular ATP levels (25, 26, 43) (Figure 1). The inhibition of mitochondrial respiration and ATP production by metformin results in a...
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암의 기원을 둘러싼 논란 - 유전자 발암설, 미토콘드리아 기능부전설 2020.01.15해당카페글 미리보기
in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other...of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The...
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chapter 5. 암세포의 호흡부전(respiratory dysfunction in cancer cells) 2020.01.18해당카페글 미리보기
of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany The phospholipid cardiolipin (CL) is...of mitochondrial membranes and plays a role in many mitochondrial processes, including respiration and energy...
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Re: Reactive Oxygen Species in the Tumor Microenvironment: 2019 리뷰 2020.10.15해당카페글 미리보기
and cellular ROS indicating these cells have higher rates of mitochondrial metabolism [108]. Furthermore, the authors found that treatment of these cells with a ROS generator (tert-butyl hydroperoxide) or a mitochondrial respiratory...
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Re:Re:Mitochondrial electron transport chain, ROS generation and uncoupling (Review 2019) 2020.02.15해당카페글 미리보기
induced respiration mediated by CII (201). Pfeiffer et al (202) demonstrated that the Caenorhabditis elegans UCP4 plays a novel role in the regulation of CII by controlling succinate transport into mitochondria. UCP4 was also deemed to...
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Re: 암(미토콘드리아 기능부전)과 저산소의 관계에 대한 논문 - 꼭 읽어야 2019.12.25해당카페글 미리보기
of respiration, changes in the mitochondrial intermediary metabolism, and an adjusted increased or decreased ROS-producing capacity. These changes determine mitochondrial biology with an outreaching impact on cell physiology...
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Mitochondrial Fission, Fusion, and Stress 2020.04.08해당카페글 미리보기
the cellular pool of mitochondria if debris is aggregated and segregated by fission in a subset of mitochondria. If deleterious components (black fibers) are asymmetrically distributed or aggregated, fission could lead to cleansing of...
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Re:Re:Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer 2020.01.17해당카페글 미리보기
oxidative respiration [7]. However, it has been demonstrated that cancer cells do not necessarily exhibit compromised mitochondrial function [8, 9], suggesting that another mechanism underlies this metabolic phenotype. Aerobic glycolysis...
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Re:Mitochondrial apoptosis: killing cancer using the enemy within 2020.01.29해당카페글 미리보기
determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9 (5): 351–365. CAS Article Google Scholar Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993) Thymocyte apoptosis induced by...
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Re: AMPK at the Nexus of Energetics and Aging 2020.11.08해당카페글 미리보기
increase respiration and enhance antioxidant defense capacity, a process termed “mitohormesis”, which requires aak-2/AMPKα (Schulz et al., 2007). Despite recent progress linking mitochondrial pathways to aging, how AMPK mediates...