카페검색 본문
카페글 본문
-
Potassium 2022.11.04해당카페글 미리보기
the exception of the ubiquitous CHON elements).[55] Potassium ions are present in a wide variety of proteins and enzymes.[56] Biochemical function Potassium levels influence multiple physiological processes, including[57][58][59] resting...
-
Dietary regulation in health and disease. 2022년 네이처 리뷰 논문 2022.10.28해당카페글 미리보기
NAD+ functions as not only a master coenzyme in redox reactions but also a cofactor for non-redox NAD+-dependent enzymes, including sirtuins and PARPs.34 NPT1 (a NAD+ synthesis enzyme) and PNC1 (encoding a vital enzyme in the NAD...
-
Mitochondrial calcium: Transport and modulation of cellular processes in h 2022.11.06해당카페글 미리보기
dehydrogenase and inorganic pyrophosphatase, may sustain the reduction of NAD+ and NADP+ cofactors. All these enzymes are highly sensitive to alterations in calcium concentration inside the mitochondrial matrix (9,11,35,36). For example...
-
Nicotinamide mononucleotide (NMN) as an anti-aging health product 2022.10.29해당카페글 미리보기
due to the depletion of NAD+ [16]. NAD+ levels in the body decrease as a consequence of increasing NAD+ consuming enzymes when aging [17]. These NAD+ consuming enzymes include NADase (CD38/CD157), poly (ADP-ribose) polymerase (PARP), NAD...
-
효소, 조효소에 대하여 2022.10.24해당카페글 미리보기
The Central Role of Enzymes as Biological Catalysts Enzymes (/ˈɛnzaɪmz/) are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme...
-
mTOR at the nexus of nutrition, growth, ageing and disease. IF 113점 논문 2022.10.29해당카페글 미리보기
us to selectively target a metabolic vulnerability in transformed cells. Besides its direct effects on biosynthetic enzymes, mTORC1 also potentiates growth by dictating large-scale changes in the metabolic fates of glucose. To generate...
-
Re: The Hallmarks of Aging 2022.10.26해당카페글 미리보기
insulin/IGF-1 signaling pathway (Jin et al., 2011). It is not clear yet whether manipulations of histone-modifying enzymes can influence aging through purely epigenetic mechanisms, by impinging on DNA repair and genome stability, or...
-
Cellular senescence: all roads lead to mitochondria 2022.10.22해당카페글 미리보기
in pyruvate dehydrogenase activity [[64]]. Additionally, enhanced glycolysis via overexpression of glycolytic enzymes phosphoglycerate mutase or glucosephosphate isomerase was shown to bypass both replicative and OIS [[65]]. Furthermore...
-
Nucleic acid - DNA, RNA, ATP, GTP, dATP의 이해 2022.10.23해당카페글 미리보기
well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the...
-
cell cycle - mitosis 교과서 2022.10.23해당카페글 미리보기
Archaea Typically, bacterial and archaeal cells grow, duplicate all major cellular constituents (DNA, ribosomes, enzymes, etc.), and then divide into two nearly identical daughter cells. This process is called binary fission (two cells...