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Re:Re:Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review) 2020.02.14해당카페글 미리보기
Wnt-target genes to initiate EMT. Furthermore, the transcription of genes involved in the mesenchymal phenotype, such as fibronectin, vimentin or N-cadherin, is increased (57). Various non-epithelial cadherins (N-cadherin), cell surface...
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Re:프로폴리스(artepillin C)의 항암기전에 대한 2018년 논문!! 2020.01.12해당카페글 미리보기
data not shown) with respect to the control group. A reduction in tumour growth was observed in the mice fed GPSE or GPSE-γCD as compared to the control group over the 3 weeks of treatment (Fig. 4B). The tumor growth data were strongly...
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Re:Re:Protein oxidation and peroxidation 2020.01.21해당카페글 미리보기
will not be covered further here in detail as they have been reviewed extensively (reviewed [1]), though a brief list is given in Table 1. Under normal circumstances the formation and reactions of these species are limited by defensive...
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Re: Role of Natural Stilbenes(레스베라트롤) in the Prevention of Cancer - 2016리뷰 2020.10.02해당카페글 미리보기
have not been found in rat plasma after treatment with Resv [153, 156]. Piceatannol conjugates could be also recycled by enterohepatic recirculation as the other stilbenes (Figure 2) [157]. A remarkable finding is that piceatannol can be...
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Re: Metformin as Anti-Aging Therapy: Is It for Everyone? 2020년 리뷰논문 2020.11.17해당카페글 미리보기
but not least, if hundreds of millions of humans take metformin, we will need to understand the consequences of...into ecosystem, as metformin is eliminated from the human body unchanged, and has already been detected in the environment...
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Re:Re:Re:메티오닌 제한식사가 수명을 높인다는 2019년 review 논문 2020.03.20해당카페글 미리보기
is detected is less clear. Interestingly, one study found that the global loss of Gcn2 did not prevent reductions in protein synthesis rates in both liver and skeletal muscle. Instead, Gcn2 deleted mice fed an SAA restricted diet...
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Re:Re:Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline 2020.02.19해당카페글 미리보기
on target cells. This is where the similarities between PNS and CNS cholinergic signaling appear to end. ACh release in the brain has classically been conceptualized as slow and tonic (Descarries et al., 1997). This idea of a “volume...
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Re:Glucose transporters in cancer – from tumor cells to the tumor microenvironment 2020.01.27해당카페글 미리보기
primary cellular target for immunotherapies including adoptive T cell therapy and immune checkpoint blockade. In the...varied levels of the glucose transporters Glut1, ‐3, ‐6 and ‐8, while other Gluts are not detected. Furthermore...
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SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates t 2020.10.19해당카페글 미리보기
3 target H4-K16 for deacetylation in vitro and can deacetylate H4-K16 in vivo when recruited to a gene. Using a highly specific antibody against the N terminus of SirT3, we found that SirT3 is transported from the nucleus to the...
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Re:The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy 2020.02.10해당카페글 미리보기
is not supposed to be curative. More likely, approaches that improve the vascular function and thus tumor oxygenation as well as the recruitment and activation of immune cells by tumor endothelial cells gained attraction also in...