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Gut microbiome and cellular senescence .. aging and disease 2022.10.09해당카페글 미리보기
Kaoutari AE, Armougom F, Gordon JI, Raoult D, Henrissat B (2013) The abundance and variety of carbohydrate-active enzymes in the human gut microbiota. Nat Rev Microbiol 11:497–504. https://doi.org/10.1038/nrmicro3050 CAS Article PubMed...
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Re: The Aging Stress Response and Its Implication for AMD Pathogenesis 2022.10.09해당카페글 미리보기
nutrients and energy signaling, proteostasis, DNA damage response (DDR), mitochondrial quality control (mtQC) and enzymes metabolizing toxic species [1]. The efficacy of these pathways declines with aging, but the process of aging is...
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Re: The Impact of Dietary Sphingolipids on Intestinal Microbiota and Gastro 2022.10.11해당카페글 미리보기
in formation of SM by the enzyme SM synthase, or to glycosphingolipids, such as cerebrosides and gangliosides, by respective enzymes. Additionally, Cer can also be produced by turnover of these more complex SLs i.e. via hydrolysis of SM...
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Cellular Senescence in Brain Aging 2022.10.07해당카페글 미리보기
is a tightly regulated process whereby modifications (methylation and acetylation of lysine) are added and removed by enzymes, the amount, regulation and function of which are altered during aging (Pal and Tyler, 2016; Gadecka and Bielak...
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Re:Epigenetic Regulation of Genomic Stability by Vitamin C 2022.10.09해당카페글 미리보기
loss of TET function leads to DNA hypermethylation and increased genomic instability. Vitamin C, a cofactor of TET enzymes, increases 5hmC formation and promotes DNA demethylation, suggesting that this essential vitamin, in addition to...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
of a ubiquitin molecule is achieved through an enzymatic sequential mechanism involving three distinct classes of enzymes12. First, the ubiquitin-activating enzyme (E1) activates the carboxyl-terminal glycine residue of a ubiquitin in...
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Re: Targeting Mitochondrial Biogenesis with Polyphenol Compounds 2022.10.07해당카페글 미리보기
acid Mice Glycyrrhizic acid (GA) had neuroprotective effects and increased memory and antioxidant-related enzymes. [108] Glycyrrhizic acid PC12 cells Mitochondrial function and biogenesis were enhanced against aluminum toxicity of...
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Re: The metabolic roots of senescence: mechanisms and opportunities for int 2022.09.30해당카페글 미리보기
is often inversely correlated, as more oxygen tends to accelerate senescence. With over 60 oxygen-consuming enzymes in the mammalian genome63, it is not surprising that oxygen levels are a key modulator of many biological processes...
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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
followed by a thioester bond formation between UBA1 and Ub (Lambert-Smith et al. 2020). Thereafter, Ub-conjugating enzymes (E2s) are recruited by the C-terminal ubiquitin-fold domain of UBA1 where Ub is transferred to the E2 enzyme...
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Re: Reprogramming the Epigenome With Vitamin C 2022.10.09해당카페글 미리보기
for use in regenerative medicine. The ability of vitamin C to potentiate the activity of histone and DNA demethylating enzymes also has clinical application in the treatment of cancer. Vitamin C deficiency has been widely reported in...