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에드거 앨런 포, 애너벨 리 2022.09.24해당카페글 미리보기
특히 등장인물이 생매장되거나 무덤에서 흡혈귀처럼 다시 살아나는 것 등으로 표현된 이 주제는 〈때 이른 매장(The Premature Burial)〉, 〈리지아(Ligeia)〉, 〈아몬틸라도의 술통(The Cask of Amontillado)〉, 〈어셔 가의 몰락(The Fall of the House...
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Gut microbiome and cellular senescence .. aging and disease 2022.10.09해당카페글 미리보기
cycle arrest and SASP, thereby hampering tissue and organ functions characteristic of aging [45] (Fig. 1). Thus, premature stress-induced models of cellular senescence have been successfully used in in vitro studies. While other...
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Re: The Aging Stress Response and Its Implication for AMD Pathogenesis 2022.10.09해당카페글 미리보기
reviewed in [3]). The impairment of the aging stress response may contribute to syndromes associated with premature aging, age-related diseases and cancer. Age-related macular degeneration (AMD) is the primary cause of legal blindness in...
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Cell cycle control in the kidney 2022.10.22해당카페글 미리보기
Dysregulation of cell cycle programme can result in cell loss and tissue atrophy, insufficient regeneration, premature senescence and thus progression of AKI in CKD, or to pathological hypertrophy and hyperplasia and scarring. The MDM2...
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Cellular Senescence in Brain Aging 2022.10.07해당카페글 미리보기
of cellular senescence characteristic for proliferation-competent cells can be distinguished, namely stress-induced premature senescence (SIPS), oncogene-induced senescence (OIS), programmed senescence (PS) taking place during...
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Re:Epigenetic Regulation of Genomic Stability by Vitamin C 2022.10.09해당카페글 미리보기
mutation signature in cancer (Alexandrov et al., 2013; Kandoth et al., 2013) loss of TET activity could mimic a premature aging phenotype with regard to the frequency at which C > T mutations accumulate. Distinct mutational signatures...
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Re: The chromatin landscape of cellular senescence 2022.10.15해당카페글 미리보기
lead to pathologies with a large variety of clinical symptoms [46]. For example, most patients with the rare premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS) carry a point mutation that leads to the activation of a...
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Poet Park Jin-gwan's 53 Seonji 18th. 4, Joseon pine wound 2022.11.16해당카페글 미리보기
on the Joseon pine tree It is a method of sucking blood from a Joseon pine tree. You know that blood flows in the premature pine Joseon Pine Tree I vomit blood, but I collect the blood The story of getting the fuel out of an airplane...
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Senolytic drugs: from discovery to translation 2022.10.03해당카페글 미리보기
induced damage to airway structure and function [133]. Supplemental O2 can be a necessary intervention in premature infants, but appears to contribute to development of neonatal and paediatric asthma. At least in cell culture, D + Q...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
with reduced chymotrypsin-like activity by replacement of the β5 subunit with β5t exhibits a shortened lifespan, premature age-related phenotypes and aggravation of age-related metabolic disorders55. Similarly, PA28γ deficiency...