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Re: The Aging Stress Response and Its Implication for AMD Pathogenesis 2022.10.09해당카페글 미리보기
Perturbation in the aging stress response may lead to aging-related disorders, including age-related macular degeneration (AMD), the main reason for vision loss in the elderly. 항산화 방어와 미토콘드리아 생합성에 중요한 역할을 하는...
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Neuronal cell cycle: the neuron itself and its circumstances 2022.10.22해당카페글 미리보기
of both TrkB and BDNF, observed in the late stages of AD,127 could participate in the induction of neuronal degeneration.84 Although the mechanisms leading to apoptosis in adult neurons that undergo G2/M transition are not fully...
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Cellular Senescence in Brain Aging 2022.10.07해당카페글 미리보기
is widespread in advanced AD as well as in Down syndrome and is frequently colocalized with neurofibrillary degeneration (Streit et al., 2020). Aged microglia are found to express increased levels of effector molecules associated with...
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Senolytic drugs: from discovery to translation 2022.10.03해당카페글 미리보기
in age‐related osteoporosis, lungs in idiopathic pulmonary fibrosis, liver in cirrhosis, retinae in macular degeneration, plaques in psoriasis, kidneys in diabetic kidney disease, endothelium in pre‐eclampsia, and the heart and major...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
by neuronal loss and premature death. Purkinje cell-specific knockout of Atg7 induces axonal dystrophy and degeneration of axon terminals with a subsequent Purkinje cell death and cerebellar ataxia. It is important to highlight these...
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Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regen 2022.10.07해당카페글 미리보기
However, aging, chronic inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and degeneration, resulting in muscular dysfunction. Cellular senescence, a state of irreversible cell cycle arrest, acts during...
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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
effects in distinct disease models, overexpression of USP14 reduces mutant HTT aggregates and counteracts cell degeneration in neural cell lines expressing expanded-polyQ HTT constructs (Hyrskyluoto et al. 2014). In addition, USP14...
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Re: Reprogramming the Epigenome With Vitamin C 2022.10.09해당카페글 미리보기
cells, sheets of retinal pigment epithelium were generated for the treatment of patients with age-related macular degeneration with reports of improved vision and a block in further degeneration (Mandai et al., 2017). However, important...
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Re: The metabolic roots of senescence: mechanisms and opportunities for int 2022.09.30해당카페글 미리보기
Furthermore, metformin protects against the development of senescence in murine models of intervertebral disc degeneration190 and chronic kidney disease191. Metformin therefore interferes with senescence at several levels and is perhaps...
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크릴 오일: 노화와 관련된 퇴화로부터 뇌를 보호할 수 있습니까? 2022.12.01해당카페글 미리보기
n Krill oil may be better than fish oil for aging and brain health Krill oil may be able to promote brain health by protecting neurons and counteracting age-related brain degeneration, according to a new study. www.medicalnewstoday.com