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Re: 공중우세 대신 공중거부(air denial)? 2022.09.13해당카페글 미리보기
is maybe that’s not what we need to do. That, politically, that’s not what we need to do,” he said. Scale versus attrition Grieco, who has written on the concept of air denial for the Atlantic Council together with Col Maximilian...
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Re: The Hallmarks of Aging 2022.10.26해당카페글 미리보기
in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction...
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Re: 러시아는 우크라이나에서 보유한 공격헬기 절반을 잃었다 2022.10.26해당카페글 미리보기
military has failed to achieve air superiority. “Russian attack helicopters have likely suffered particular attrition from Ukrainian man-portable air defence systems (MANPADS), while the helicopters frequently operate with less...
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Re: Mitochondrial dysfunction in cell senescence and aging 2022.10.22해당카페글 미리보기
since mitochondria play a role in nucleotide synthesis, mitochondrial dysfunction may affect telomere attrition and genome stability via attrition of nucleotide pools (109). Importantly, in telomere-dependent (including replicative and...
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Re: Turning back time with emerging rejuvenation strategies 2022.10.26해당카페글 미리보기
elsewhere1,2). At the molecular level, ageing hallmarks comprise DNA damage, epigenetic alterations, telomere attrition, protein aggregation and accumulation of aberrant mitochondria and lysosomes1,2. At the cellular and organismal level...
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senolytics, 세포 노화의 처리 2022.10.03해당카페글 미리보기
can occur in response to cellular or DNA damage [18], oncogene, mitogen and cytokine signalling [19], telomere attrition/shortening [20], ionizing radiation [21] and anti-cancer drugs [22]. (c) Cellular senescence plays a dual role...
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Gut microbiome and cellular senescence .. aging and disease 2022.10.09해당카페글 미리보기
senescence program [58]. However, it is interesting to note that oxidative stress can also accelerate telomere attrition suggesting that the chronic presence of different stressors can rapidly induce/augment different (oxidative...
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Re: The chromatin landscape of cellular senescence 2022.10.15해당카페글 미리보기
in cell culture). Replicative senescence An irreversible arrest to the cell-cycle that is caused by telomere attrition due to the accumulation of cell-divisions. Oncogene-induced senescence An arrest to the cell-cycle caused by the...
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Re:Epigenetic Regulation of Genomic Stability by Vitamin C 2022.10.09해당카페글 미리보기
2012; Tsoukalas et al., 2019), however, direct evidence that vitamin C supplementation alone can suppress telomere attrition in vivo requires further study. Using in vitro cellular models derived from human iPSCs, vitamin C treatment has...
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Re: Targeting the molecular & cellular pillars of human aging with exercise 2022.10.08해당카페글 미리보기
nuclear DNA repair systems cause accelerated aging in mice and in human progeroid syndromes [[22-24]]. Telomere attrition during somatic cell division constitutes another type of age-related chromosomal deterioration and has been linked...