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Nutrient Sensing Mechanisms and Pathways 2022.10.30해당카페글 미리보기
sensing domain reminiscent to that of SCAP, are embedded in the ER membrane23. High levels of intermediate lipid species in cholesterol synthesis, such as lanosterol, trigger the binding of HMG-CoA reductase to INSIG, which is also bound...
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Re: Re:Re: 미토콘드리아 기능부전 운동- 알츠하이머를 치료하는 방법 2022.09.21해당카페글 미리보기
mitochondrial-specific protease presenilin-associated rhomboid-like (PARL) (Kane et al., 2014). However, in compromised and depolarized mitochondria, PINK1 is accumulated in the outer membrane of mitochondria (OMM) (Cadete et al., 2019...
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Re: Re: ER stress and hepatic lipid metabolism 2022.09.30해당카페글 미리보기
terminal domain) is translocated to the nucleus and functions as a transcription factor, promoting the expression of downstream target genes involved in ER stress including XBP1, GADD153 (also known as CHOP), and ER chaperones (Oyadomari...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
neuron-specific KO of Atg7, results in only subtle cytosolic accumulation of p62 and ubiquitin, with no TDP-43 and FUS pathologies or motor dysfunctions113. Therefore, under these experimental settings, proteasomal degradation appears to...
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nature) 2002.06. Angiotensin-converting enzyme 2 is an essential regulator 2022.09.27해당카페글 미리보기
myocyte-specific vascular endothelial growth factor mutant mice30. Thus, loss of ACE2 results in the induction of a hypoxia-regulated gene expression profile. Figure 4: Upregulation of hypoxia markers and increased angiotensin II levels...
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Copper promotion of myocardial regeneration(심근 재생의 구리 촉진) 2022.10.27해당카페글 미리보기
실라제 도메인 함유 단백질(PHD)에 의해 인식되어 수산화 반응을 촉매합니다. 33 , 37 ,38 수산화된 HIF-1α는 유비퀴틴 리가제 복합체의 폰 히펠-린다우 단백질(pVHL)에 의해 인식되어 프로테아좀에 의한 HIF-1α 소단위의 분해로 이어집니다. 39 , 40...
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[영화 대본] ‘Snow White and the Fairy Tale Fun Force(백설 공주와 그 동화의 재미의 힘, 2023) 2023.02.10해당카페글 미리보기
in specific places. Cats are creatures of habit, you know? - Oh, those poor defenseless wicker baskets, just sitting there, waiting to be pooped in. It breaks my heart. - You can communicate with wicker? - Yes ma'am. I am made out of...
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β-Hydroxybutyrate - 꼭 읽어야!! 2022.09.22해당카페글 미리보기
deacetylase domain, and are usually found in large regulatory multiprotein complexes. Histone hyperacetylation is generally associated with activation of gene expression; so as a broad generality, class I HDAC activity suppresses gene...
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The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans 2022.10.10해당카페글 미리보기
of specific comment is the randomized, placebo controlled trial of oral glutamine in about 100 patients showing normalization of LMR in association with improvement in the IBS-SSS (symptom severity score), stool frequency and consistency...
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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
C-terminal ubiquitin-fold domain of UBA1 where Ub is transferred to the E2 enzyme (Hershko and Ciechanover 1998). The...intermediate dissociates from UBA1 and, together with the target protein, binds to a specific E3 ubiquitin ligase...