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Re: The metabolic roots of senescence: mechanisms and opportunities for int 2022.09.30해당카페글 미리보기
extends lifespan in mice184 and prevents diet-induced atherosclerosis-associated senescence in rabbits185. Another...metformin, extends both lifespan and health span in mice186, and is a drug being studied for the first clinical trial...
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Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regen 2022.10.07해당카페글 미리보기
senolytic drug ABT263 decreases cardiomyocyte proliferation and increases proliferation of PDGFRα+ fibroblasts, thus...Feng et al., 2019). Another study found that treatment with the extracellular matrix molecule agrin induced transient...
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Disea 2022.10.02해당카페글 미리보기
a drug-resistant phenotype (93). Downregulation of UCP3 increases oxidative damage, impairs fatty acid oxidation, and...cardiac function (94), whereas overexpression of UCP3 in skeletal muscle protects against high-fat diet-induced IR...
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The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans 2022.10.10해당카페글 미리보기
non-drug intervention Table 2 summarizes the literature on two types of conditions that result in stress to the intestinal barrier, with documented effects on intestinal permeability or biochemical evidence of mucosal damage, and...
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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
overcome drug resistance (Frankel et al. 2000; Hideshima et al. 2001). A potential explanation for this selectivity is that malignant cells show greater sensitivity to the cytotoxic effects of proteasome inhibition compared with non...
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Re: Reprogramming the Epigenome With Vitamin C 2022.10.09해당카페글 미리보기
by induced by C/EBPα in reprogramming B cells promotes 5hmC formation and DNA demethylation at enhancers and promoters of pluripotency genes and Tet2 is physically recruited to the chromatin of reprogramming cells via interaction with C...
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새로운 항암 치료 / 면역관문억제제 2022.10.18해당카페글 미리보기
ligand-induced T cell receptor down-modulation on CD8+ T cells”. 《EMBO Molecular Medicine》 3 (10): 581–92. doi:10.1002/emmm.201100165. PMC 3191120. PMID 21739608. ↑ Syn NL, Teng MW, Mok TS, Soo RA (December 2017). “De-novo and...
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Re: Lysosome biology in autophagy .. 2020 논문 2022.09.20해당카페글 미리보기
starvation-induced V-ATPase assembly is independent of mTORC1 activity74, suggesting that lysosomal activation, at least in terms of acidification, is not regulated by mTORC1 activity and may be linked to autophagosome formation. However...
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Neuroinflammation: A Potential Risk for Dementia 2022.09.20해당카페글 미리보기
Curr. Drug Targets-CNS Neurol. Disord.) 2021;20:704–722. doi: 10.2174/1871527319666201209112256. [PubMed] [CrossRef] [Google Scholar] 8. Sartori A.C., Vance D.E., Slater L.Z., Crowe M. The impact of inflammation on cognitive function in...
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Re: Turning back time with emerging rejuvenation strategies 2022.10.26해당카페글 미리보기
mechanism induced by stress that prevents propagation of damaged cells55,56. Initially identified as a barrier against tumour development56, senescence is now known to be involved in tissue remodelling during embryogenesis57,58, wound...