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mTOR at the nexus of nutrition, growth, ageing and disease. IF 113점 논문 2022.10.29해당카페글 미리보기
to tune the balance of anabolism and catabolism in the cell, while mTORC2 governs cytoskeletal behaviour and activates several pro-survival pathways. Unlike mTORC1, which is acutely inhibited by rapamycin, mTORC2 responds only to chronic...
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말씀의 실재 2022년11월28일 ㅡ펌ㅡ 2022.11.28해당카페글 미리보기
내 ”필요”는 내 믿음을 활성화시킵니다 Your “Need” Activates Your Faith 【하나님을 믿으라. 내가 진실로 너희에게 이르노니 누구든지 이 산더러 “들리어 바다에 던져지라” 하며 그 말하는 것이 이루어질 줄 믿고 마음에 의심하지 아니하면 그대로...
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말씀의 실재 2023년6월27일 ㅡ펌ㅡ 2023.06.27해당카페글 미리보기
내 ”필요”는 내 믿음을 활성화시킵니다 Your “Need” Activates Your Faith 【하나님을 믿으라. 내가 진실로 너희에게 이르노니 “누구든지 이 산더러 ‘들리어 바다에 던져지라’ 하며 그 말하는 것이 이루어질 줄 믿고 마음에 의심하지 아니하면...
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Nucleic acid - DNA, RNA, ATP, GTP, dATP의 이해 2022.10.23해당카페글 미리보기
of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. When UTP activates a substrate (like Glucose-1-phosphate), UDP-glucose is formed and inorganic phosphate is released.[5] UDP-glucose...
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Topic for Nov. 29. ( Tue ) 2022.11.25해당카페글 미리보기
brain as well as increased activity in the part of the brain that is responsible for sexual behavior and normally activates after exposure to a female rat. The double messages of “you smell a cat but he’s not dangerous” and “that cat...
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Cellular senescence: all roads lead to mitochondria 2022.10.22해당카페글 미리보기
NLR family pyrin domain containing 3 (NLRP3) by DAMPs, which by oligomerization forms the NLRP3 inflammasome and activates caspase-1. Once activated, caspase-1 matures pro-IL1-β and pro-IL18 into IL-1β and IL-18 respectively [[135...
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cell death를 일으키는 미토콘드리아 기능의 손상지점 - membrane permeablization 2022.10.21해당카페글 미리보기
a molecular platform which promotes the proteolytic maturation of caspase-9. Active caspase-9, in turn, cleaves and activates the effector caspases, which finally lead to the apoptotic phenotype. DNA damage may signal also through the...
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Nutrient Sensing Mechanisms and Pathways 2022.10.30해당카페글 미리보기
at the plasma membrane, and culminating with the activation of the Rheb GTPase. Rheb directly binds mTORC1 and activates its kinase in a growth factor-dependent manner49-52. In addition to the regulation by protein hormones...
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Re: Caloric Restriction Mimetics against Age-Associated Disease - 꼭 읽어 2022.10.29해당카페글 미리보기
the regulation and execution of autophagy, nutrient signaling, and energy metabolism (Figure 1). For instance, CR activates AMP-activated protein kinase (AMPK) ( Cantó and Auwerx, 2011 ). AMPK is an energy sensor that inhibits the...
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Re: Lactate: the ugly duckling of energy metabolism 2022.10.25해당카페글 미리보기
pyruvate clearance and thereby promotes cellular lactate excretion and systemic 3C-compound accumulation. NADH activates PDK and thereby inhibits PDH, thus contributing to the elevated circulating lactate in patients with impaired...