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Cellular senescence: all roads lead to mitochondria 2022.10.22해당카페글 미리보기
that maintain the senescence cell-cycle arrest. This occurs because telomere-binding proteins, such as TRF2, inhibit DNA repair [[76-78]] potentially to avoid chromosomal fusions and maintain the linear structure of chromosomes. Thus, as...
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미량 원소 리튬 - bipolar disorder 2019년 논문 2022.11.06해당카페글 미리보기
by acting on phosphatidylinositol and adenylyl cyclase systems [25, 27–29]. It has also been shown to inhibit the activity of glycogen synthase kinases, associated with cell proliferation, metabolism, and apoptosis [7, 20, 30]. In...
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defender's foul 수비수 반칙 2022.12.14해당카페글 미리보기
attempt 본인이 시도하려했던 것을 그르치기 십상이다 fluff 망치다, 실패하다 (=bungle 엉망(으로 하다), 실수(하다)) inhibit their usual performance 평소 실력을 망가뜨리다 inhibit 억제[저해]하다, 못하게 하다, 제약을 가하다 make an egregious...
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Re: Caloric Restriction Mimetics against Age-Associated Disease - 꼭 읽어 2022.10.29해당카페글 미리보기
which instead promotes the deacetylase activity of SIRT1 (see above). Moreover, spermidine has been shown to inhibit mTORC1 and activate AMPK ( Mariño et al., 2014 ). It has also been speculated that spermidine might post-translationally...
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RE:서울식물원 69-2 Dutchman's-pipe 콩배단풍 2022.10.21해당카페글 미리보기
familiar to Europeans when discovered and they have since become a popular garden plant. Poor or sandy soils do not inhibit a showy display, the species is hardy and adaptable. Hibbertia vestita Species of shrub Hibbertia vestita...
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Copper promotion of myocardial regeneration(심근 재생의 구리 촉진) 2022.10.27해당카페글 미리보기
is an asparaginyl hydroxylase in the nucleus, catalyzing hydroxylation of asparagine in the C-terminal of HIF-1α, to inhibit the formation of HIF-1 transcriptional complex, leading to suppression of genes expression. HIF-1은 허혈성 손상...
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muscle stem cell(satellite cell) senolytics 그림이해 2022.10.08해당카페글 미리보기
On the other hand, altered ATP:AMP ratio, altered redox balance, and AMPK activation mediated by reduced tissue oxygen inhibit SASP expression, and NAD + metabolism and HIF-1 activation inhibit senescence. The outcome of exercise-induced...
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Re: Turning back time with emerging rejuvenation strategies 2022.10.26해당카페글 미리보기
blood revitalize aged organs and tissues? Young blood may contain pro-rejuvenation factors, or it could dilute or inhibit pro-ageing factors in aged blood (Fig. 2). The pro-rejuvenation effect of young blood on the liver, muscle and...
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mitochondria dysfunction 그림 이해 2022.10.03해당카페글 미리보기
complementation among mitochondria (Fig. 1). Fusion is also enhanced by treatments that directly or indirectly inhibit protein synthesis and by starvation and mTOR (mammalian target of rapamycin) inhibition–induced autophagy (10–12...
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Cell cycle control in the kidney 2022.10.22해당카페글 미리보기
Thy-1 nephritis in rats which, if left to run its course, resolves within a few weeks. Any therapy designed to inhibit MC proliferation may potentially limit these beneficial healing processes. BALANCING THE CELL CYCLE—P53 AND MDM2 P53...