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Re:Re: Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise 2020.06.24해당카페글 미리보기
in yeast is sufficient to confer enhanced thermotolerance, suggesting that proteotoxicity is the primary cause of cell death.173 In contrast to the situation in unicellular eukaryotes, a careful balance is struck between Hsp-mediated...
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Re:Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease - review 논문 2019.12.30해당카페글 미리보기
neuroblastoma cell line [51], respectively. In 1999, MITOP database was released [52]. It was the first database for both nuclear- and mitochondrial-encoded proteins, comprising genetic and functional information on five species...
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Re:Re:The Mitochondrial Basis of Aging and Age-Related Disorders 2019.12.22해당카페글 미리보기
including yeast, worms, flies and mice [191,198]. However, the precise mechanisms by which UPRmt pathway promotes longevity remain poorly understood. Moreover, the molecular components including sensors and signal transduction effectors...
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Re:The role of mitochondrial dysfunction in age-related diseases 2019.12.21해당카페글 미리보기
in yeast grown on media with reduced glucose [10]. Mitochondria also appear to be major signaling hubs that in part govern the molecular changes induced by dietary restriction [11]. Current evidence points to mitochondrial dysfunction as...
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Re:8. 프리바이오틱스 암치유 관련 논문 - 2019년 2020.02.02해당카페글 미리보기
whole cell. Temperature often increases the yield of GOS synthesis, which is undesirable and even fatal for non-thermophilic cells. In some studies, non-viable and resting cells are exploited. These kinds of cells do not have the...
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Re:Re:세포의 마그네슘 항상성에 관한 논문 2020.06.28해당카페글 미리보기
plants and yeast and not in mammalian/human cells. 3.1 Channels Channels favoring Mg2+ entry into the cell were...in prokaryotes [39, 40] and protozoan [41]. Recently, several Mg2+ entry mechanisms with channels or channels-like features...
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Re:Re:Mitochondria: The calcium connection 2020.05.28해당카페글 미리보기
in yeast, mammals and Drosophila [81], [82], [83]. In their recent paper, Jiang and co-workers, on the contrary, demonstrate in intact and permeabilized cells that Letm1 down-regulation reduces mitochondrial Ca2+ increases (at low [Ca2...
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Re:셀레늄 - 글루타치온 페록시다제 활성화하여 항산화, 항암 효과 2020.01.31해당카페글 미리보기
enriched yeast to patients with completely resected stage I non-small-cell lung cancer [34]. Despite these negative findings, most of these trials suggested that Se supplement was safe to consume. Thus, organic Se may be useful in cancer...
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Re: Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation - 논문 읽어야!! 2019.11.30해당카페글 미리보기
of cell protective reactions require a mode of “BA sensing” in exposed cells. A new era of BA research was initiated in 1999, when BAs were identified as the natural ligands of the nuclear receptor farnesoid X receptor/bile acid...
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Membrane Repair: Mechanisms and Pathophysiology 2020.07.04해당카페글 미리보기
activation, cell swelling due to altered sodium/potassium homeostasis, oxidative damage, and in the case of cardiac...mechanical injury of a damaged plasma membrane. The heart cannot stop beating. Like skeletal muscle injury, ischemic...