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11월28일(월) 당신의 “필요”는 당신의 믿음을 활성화시킵니다 2022.11.25해당카페글 미리보기
당신의 “필요”는 당신의 믿음을 활성화시킵니다 Your “Need” Activates Your Faith “예수께서 그들에게 대답하여 이르시되 하나님을 믿으라 내가 진실로 너희에게 이르노니 누구든지 이 산더러 들리어 바다에 던져지라 하며 그 말하는 것이 이루어질...
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Re: Mitochondrial dysfunction in cell senescence and aging 2022.10.22해당카페글 미리보기
factor that regulates mitochondrial biogenesis and plays a fundamental role in mtDNA transcription (64). PGC-1α activates the transcription factors Nrf1/2 and ERRα, which further control the TFAM transcription in response to increased...
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Re: Hallmarks of Cellular Senescence. 2018년 리뷰논문 2022.10.24해당카페글 미리보기
directly onto the chromatin at DSBs, leading to the methylation of H3K9. H3K9me3 functions as a binding site and activates the acetyltransferase Tip60, which subsequently acetylates and activates ATM [11]. Therefore, H3K9 methylation is...
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Re: The Aging Stress Response and Its Implication for AMD Pathogenesis 2022.10.09해당카페글 미리보기
Figure 1 Nutrition signaling includes proteins and signaling pathways important in aging. Dietary restriction activates 5’AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) but inhibits the insulin growth factor 1 (insulin/IGF...
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Cell cycle control in the kidney 2022.10.22해당카페글 미리보기
Wnt and microRNAs regulate the accurate proliferation and differentiation of podocyte progenitor cells. Notch activates renal progenitor cells to enter the S-phase of the cell cycle and successive cell division, while Notch suppression...
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Neuronal cell cycle: the neuron itself and its circumstances 2022.10.22해당카페글 미리보기
specific Cdks, activating their kinase activity.3 Cyclin D is synthesized at the beginning of G1, and it binds and activates Cdk4/6 when the cell leaves the quiescent state. Cdk4/6 phosphorylates Rb protein, inducing the release of the...
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Re: The Impact of Dietary Sphingolipids on Intestinal Microbiota and Gastro 2022.10.11해당카페글 미리보기
of degradation, an accumulation of Cers may occur provoking excessive apoptosis. Tumor necrosis factor (TNF)-α activates SMases leading to an accumulation of Cers. Elevated TNF-α levels are associated with lipotoxicity by activation of...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
enzymatic sequential mechanism involving three distinct classes of enzymes12. First, the ubiquitin-activating enzyme (E1) activates the carboxyl-terminal glycine residue of a ubiquitin in an ATP-dependent manner. Activated ubiquitin is...
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Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regen 2022.10.07해당카페글 미리보기
ARF (Lazzerini Denchi et al., 2005). Another DDR-independent inducer of cellular senescence is BRAF (V600E), which activates senescence through a metabolic mechanism involving upregulation of mitochondrial pyruvate dehydrogenase (Kaplon...
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Re: Targeting Mitochondrial Biogenesis with Polyphenol Compounds 2022.10.07해당카페글 미리보기
of histone acetyltransferase 1 by AMPK lead to a far less constricted chromatin-DNA structure that ultimately activates transcription. Besides, phosphorylation of DNA methyltransferase 1 as an epigenetic factor, aka DNMT1 by AMPK...