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만성염증 --> 자가면역 염증으로 진행하는 과정의 중요 인자 NF-κB 탐구!! 2024.07.04해당카페글 미리보기
to timing – that is, before, during, or after pre-antigen receptor signaling. Although no single NF-κB-subunit-knockout mouse has as severe a phenotype as NEMO knockouts with regard to the generation of mature lymphocytes, double...
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파킨슨 병리 ... jama 논문.. 2024.07.10해당카페글 미리보기
in ARJP. Moreover, steady-state levels of the known parkin substrates were surprisingly unaltered in the parkin knockout mouse.7,8 Two-dimensional gel electrophoresis followed by mass spectrometry analysis revealed a decrease in the...
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Re: 산화질소, 황화수소 gaseous signaling 치료전략 2024.05.29해당카페글 미리보기
In this same study, myocardial oxidative stress and eNOS uncoupling were significantly increased in the CSE knockout mouse. The authors treated the CSE-deficient mice with H2S donor therapy for 7 days and reported significant increases...
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건선 .. 각질세포 과증식.. 자가면역... 2024.06.24해당카페글 미리보기
patients and IMQ-induced psoriasis mouse model. IL-17E injection caused psoriasis-like pathology in mouse skin, whereas global knockout of IL-17E ameliorated IMQ-induced psoriasis. Specially, IL-17E deficiency in keratinocytes could lead...
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Re: Cathepsin B in programmed cell death machinery 2024.02.02해당카페글 미리보기
evidence of the pathophysiological roles and substrates of CatB has been reported following the establishment of CatB knockout mouse in 2000 [4]. CatB is synthesized as inactive pre-proenzymes and modified in their N‐glycosidically...
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Mitochondrial dynamics in health and disease: 2023년 Nature reveiw 2024.01.27해당카페글 미리보기
inactivation mutations results in the formation of elongated tangles and collapses of mitochondria.38 The knockout of mouse Drp1 through genetic engineering results in embryonic lethality, indicating the crucial role of Drp1-dependent...
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Re: 비타민 D anticancer mechanism 2023.10.27해당카페글 미리보기
suppression of p65 activation in colon cancer cells [106]. Consistent with the previous results, double knockout of VDR in mouse embryonic fibroblasts leads to a marked decrease in the basal levels of IκB compared to VDR+/− as shown by...
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Knock-out mouse 질문입니다. 2014.04.04해당카페글 미리보기
16장 Knockout mouse 만드는 과정에서, 간단한 의문이 들어 질문합니다. 과정은 다 잘 이해가 되는데, F2세대에서 갈색 쥐들을 얻어서 AA 와 AA'형을 구분하기 위해서 꼬리를 잘라서 PCR이나 서던블롯으로 확인해야 한다고 하셨는데, A' 유전자에 NeoR...
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상호 발전해가는 우크라이나와 러시아의 무인기 운용전술 2023.12.15해당카페글 미리보기
and-mouse game moves so rapidly, Ukrainian and NATO experts said at the Association of Old Crows’ annual electronic warfare conference, that tech needs to be upgraded about every eight weeks. RELATED: Amid Ukraine and Israel conflicts...
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루게릭 병 발생 기전 - autophagy and/or mitophagy 2023.09.08해당카페글 미리보기
conditional knockout (cKO) mice. Crossing Atg7-cKO mice to mice expressing mutant SOD1 led to some counter-intuitive findings. The deficiency in autophagy induced by depletion of Atg7 led to an earlier disease onset by some but not all...