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Re: HDACs, histone deacetylation and gene transcription: from molecular bio 2020.10.19해당카페글 미리보기
in carbon metabolism, Rpd3 controlling primarily cell cycle genes and Sir2 emerging as a player in the regulation of amino-acid biosynthesis. Transcriptional profiles of Sin3 mutants showed striking similarity to Rpd3 mutants, in line...
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Re: Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Fa 2020.10.16해당카페글 미리보기
double carbon bond that allows four diastereoisomers to form from two chiral centers [194]. These phytochemicals are commonly found in chocolate, in the skins of apples and berries as well as in teas. Notably, epigallocatechin gallate...
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Re: Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer 2020.10.14해당카페글 미리보기
LPS activated macrophages, and this was associated to reduced mitochondrial respiration, ROS production, HIF-1 pseudohypoxic activation, pro-inflammatory cytokine release, and inflammasome activation (84). Although itaconate plays...
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Re: Role of tumor microenvironment in tumorigenesis 2020.10.14해당카페글 미리보기
removing carbon dioxide and metabolic wastes for sustaining the survival of neoplasm growth. These networks have two main features. First, the new vessels surrounding tumors are usually inefficient, tortuous, or leaky 133. Second, the...
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Modulation of Colitis-associated Colon Tumorigenesis by Baicalein, Betaine 2020.10.13해당카페글 미리보기
proliferator-activated receptor (PPAR)γ. As a result, baicalein suppressed the expression of the inflammatory mediator iNOS.28 The anti-inflammatory activity of baicalein is mediated not only by NF-κB but also by modulation of various...
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Gut microbes and metabolites as modulators of blood-brain barrier integrity 2020.10.12해당카페글 미리보기
are activated, their morphology changes in association with increased secretion of pro-inflammatory cytokines, such as IFN-γ, IL-6, and TNF-α, and the release of reactive oxygen and nitrogen species,10 which can lead to neuronal cell...
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Re: 단쇄지방산 중 뷰티르산의 항염증, 항암효과 2020.10.12해당카페글 미리보기
four-carbon short-chain fatty acid, is produced through microbial fermentation of dietary fibers in the lower intestinal tract. Endogenous butyrate production, delivery, and absorption by colonocytes have been well documented. Butyrate...
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Re:단쇄지방산 중 아세테이트의 식욕조절 기전 2020.10.12해당카페글 미리보기
of carbon-11 (11C) i.v. acetate as determined using PET scanning. Image depicts a fasted mouse following i.v. infusion. Image shows uptake in the brain, liver and heart. (e–g) Brain, liver and heart uptake of i.v. and colon infused 11C...
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Re: SAM-e 보충제의 간기능 보호, 항암효과 2020.10.12해당카페글 미리보기
and carbon atoms on proteins, nucleic acids, carbohydrates, lipids, and small molecules. The most abundant AdoMet-dependent MT in liver is glycine N-methyltransferase (GNMT), where it accounts for 1% of cytosolic protein (147, 237...
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Re: 함황아미노산 대사과정의 타우린의 생성 2020.10.12해당카페글 미리보기
or activated to 3′-phosphoadenosine-5′-phosphosulfate, which, in turn, serves as a sulfate donor for sulfate ester formation. Sulfite oxidase is a heme-containing enzyme that is a member of the cytochrome b5 family and contains a...