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히스톤 메틸화 - dynamic mark in health, disaease, inheritance(유전) 2020.09.12해당카페글 미리보기
causes cell proliferation and increased HoxA9 expression and mutation of this fusion protein’s DNA binding or recruitment domains prevented leukemic transformations111. Interestingly, MLL1 has roles in proliferation of normal...
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Re: 열충격단백질 - 항암치료 - 2020년 Cells 논문 2020.09.05해당카페글 미리보기
and c-Src/LSF/TS signaling axes, respectively. [108,110]. Various drug-resistant cancer cell lines have increased expression of HSP90 and concomitantly increased activations of pro-survival signaling pathways and cell cycle progression...
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세포막 - 인지질 이중층(lipid bilayer) 2020.09.02해당카페글 미리보기
formula, (C) as a space-filling model, and (D) as a symbol. The kink resulting from the cis-double bond is exaggerated for emphasis. It is the shape and amphipathic nature of the lipid molecules that cause them to form bilayers...
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Re:The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated c 2020.09.02해당카페글 미리보기
Fc fusion proteins (Table 1) (supplementary Appendix and Figure S1, available at Annals of Oncology online). Several of these agents are showing favorable clinical toxicity profiles and promising antitumor activity has been reported in...
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Re: Phosphatidylserine in the Brain: Metabolism and Function - 꼭 다시 읽어야 2020.09.02해당카페글 미리보기
kinase C and Raf-1 requires translocation from the cytosol to the cytoplasmic surface of the plasma membrane. Translocation is initiated by specific stimuli, for example, growth factor-dependent PIP3 generation from PIP2 by PI3 kinase in...
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Re: Engulfment signals and the phagocytic machinery for apoptotic cell clea 2020.09.02해당카페글 미리보기
the C terminus. They bind to phosphatidylserine in a calcium-dependent manner via their Gla domain and associate with Tyro3–Axl–Mer (TAM) family tyrosine-kinase receptors on phagocytes through laminin G-like domains.86, 87 Mer tyrosine...
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Re: An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure - cell 리뷰논문 2020.09.02해당카페글 미리보기
cell fusion [29], mineral deposition in osteoblasts [30], and other processes. However, once established, PtdSer asymmetry is disrupted only slowly by passive diffusion (t1/2 of several days) [31]. These observations led to the...
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Re: The caspase‐activated DNase: apoptosis and beyond 2020.09.02해당카페글 미리보기
cytochrome c from the mitochondria into the cytoplasm that initiates caspase signaling, the activation of CAD, and telomeric DNA damage. Hain et al. [31] recently explored the significance of the CAD‐induced telomeric DNA damage, and...
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Re: Re: Autophagy: Renovation of Cells and Tissues - cell 리뷰논문 2020.08.26해당카페글 미리보기
lysosome fusion ( Nishino et al., 2000 ). Patients with XMEA show similar morphological features to those with Danon disease, implying abnormality of lysosomal function ( Malicdan et al., 2008 ). Autophagy is also implicated in the...
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Re: Autophagy: cellular and molecular mechanisms 2020.08.26해당카페글 미리보기
phagophore; (c) LC3 processing and insertion into the extending phagophore membrane; (d) capture of random or selective...completion of the autophagosome accompanied by recycling of some LC3-II/ATG8 by ATG4, followed by; (e) fusion of...