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Re: cell death의 기전과 명명법 2018년 학회 2022.10.20해당카페글 미리보기
been employed to classify cell death into three different forms: (1) type I cell death or apoptosis, exhibiting cytoplasmic shrinkage, chromatin condensation (pyknosis), nuclear fragmentation (karyorrhexis), and plasma membrane blebbing...
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Re: The chromatin landscape of cellular senescence 2022.10.15해당카페글 미리보기
clear whether H1 depletion is a consequence of the ejection of chromatin into the cytoplasm also known as cytoplasmic chromatin fragments), a decrease in histone synthesis, or other mechanisms [40, 43, 44]. Loss of DNA association with...
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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
Dudkin et al. 2001; Yu et al. 2001). Macroautophagy starts with the formation of a phagophore, a vesicle surrounding cytoplasmic material, which turns into the so-called autophagosome. In yeast, autophagosome formation requires 18...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
lesser extent, small components of the cytoplasm are engulfed directly by the lysosome membrane14. In CMA, particular cytoplasmic proteins are recognized by chaperones through a consensus sequence and transferred to the lysosome for...
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Re: Targeting the molecular & cellular pillars of human aging with exercise 2022.10.08해당카페글 미리보기
respectively. These observations were in contrast to different muscle fiber types, where the median half-lives of cytoplasmic proteins from soleus muscle fibers (slow-twitch) obtained from young and old C57BL/6 female mice were 16.4 and...
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Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regen 2022.10.07해당카페글 미리보기
identified. Consequently, combinations of biomarkers, such as nuclear (p16INK4a, p21WAF1/Cip1, Ki67, γH2AX), cytoplasmic (SA-β-gal), SASP, context, and cell-type-specific markers, are generally used to define the presence of senescence...
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Cellular Senescence in Brain Aging 2022.10.07해당카페글 미리보기
process length), appearance of morphological changes suggestive of increased activation state (e.g., perinuclear cytoplasmic hypertrophy, retraction of processes), appearance of dystrophic microglia in aged human brains, decrease in the...
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senolytics, 세포 노화의 처리 2022.10.03해당카페글 미리보기
to the loss of lamin B1 and exclusion of the high mobility group protein B1 (HMGB1), accompanied by the emergence of cytoplasmic chromatin fragments (CCFs). Senescent cells have increased lysosomal content, as manifested by elevated β...
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Disea 2022.10.02해당카페글 미리보기
output). This response may regulate several cellular functions, generating a negative feedback on the input. (B) Cytoplasmic signals induce morphological and functional changes in mitochondria that regulate several intracellular...
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Current understanding of metal ions in the pathogenesis of Alzheimer’s dise 2022.10.01해당카페글 미리보기
that the intracellular calcium overload can promote Aβ production and aggregation. For instance, the elevated cytoplasmic Ca2+ by inhibiting of sarcoplasmic/endoplasmic reticulum (S/ER) calcium ATPase (SERCA) or liberating Ca2+ release...