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Dysfunction of Mitochondrial Ca2+ Regulatory Machineries in Brain Aging and 2022.11.06해당카페글 미리보기
Area-Gomez, E., de Groof, A., Bonilla, E., Montesinos, J., Tanji, K., Boldogh, I., et al. (2018). A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease. Cell Death Dis. 9:335. doi: 10.1038/s41419-017-0215-0 Pub...
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Mitochondrial calcium: Transport and modulation of cellular processes in h 2022.11.06해당카페글 미리보기
in gastric cancer cell lines established from malignant ascites (61). Conversely, IP3R-3 is involved in mediating pro-apoptotic Ca2+ signals from the ER to mitochondria in HeLa cells (62). Although IP3R-3 colocalizes more closely with...
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Nutrient Sensing Mechanisms and Pathways 2022.10.30해당카페글 미리보기
GPR120. Nat Med. 2005;11:90–94. [PubMed] [Google Scholar] 6. Oh DY, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010;142:687–698. [PMC free article] [PubMed...
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mTOR at the nexus of nutrition, growth, ageing and disease. IF 113점 논문 2022.10.29해당카페글 미리보기
more tightly associated than their human counterparts and have been reported to form a supercomplex without any mediating proteins272. A. thaliana, Arabidopsis thaliana; CASTOR, cellular arginine sensor for mTORC1; H. sapiens, Homo...
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Re: Intercellular mitochondrial transfer as a means of tissue revitalizatio 2022.10.26해당카페글 미리보기
without functional mitochondria.73 In addition, we found that ER–mitochondria contact plays a crucial role in mediating the transfer of mitochondria between osteocytes.73 Intriguingly, mitofusion 2 (Mfn2), a tethering protein involved...
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Re: Turning back time with emerging rejuvenation strategies 2022.10.26해당카페글 미리보기
functions compared to age-matched wild-type mice21,23. Other systemic signalling pathways have been implicated in mediating the pro-ageing effect of aged blood16,17,28-31. For example, heterochronic parabiosis reverses the excessive Wnt...
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Re: The Hallmarks of Aging 2022.10.26해당카페글 미리보기
In mice, there are four FOXO members, but the effect of their over-expression on longevity and their role in mediating increased healthspan through reduced IIS have not yet been determined. Mouse FOXO1 is required for the tumor...
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Cardiac Myocyte Cell Cycle Control in Development, Disease and Regeneration 2022.10.22해당카페글 미리보기
phase, while cyclin B and Cdc2 are required during G2/M phase. E2F is required for the transcription of genes involved in mediating G1 exit and DNA synthesis (163). Figure 1 Regulation of cardiac cell cycle Schematic diagram of the...
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Cellular senescence: all roads lead to mitochondria 2022.10.22해당카페글 미리보기
of telomere damage, and eventually leading to cellular senescence. Consistent with a role for ROS in mechanisms mediating telomere maintenance, recent studies have shown that oxidative modifications at telomeres can accelerate telomere...
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Re: 만성염증의 이해 2022.10.21해당카페글 미리보기
such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE). A defect in the cells responsible for mediating inflammation leading to persistent or recurrent inflammation, such as auto-inflammatory disorders (Familial...