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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
thioester intermediate dissociates from UBA1 and, together with the target protein, binds to a specific E3 ubiquitin ligase (Hershko and Ciechanover 1998). Then, E3 ligases catalyze the covalent attachment of Ub to the target protein. In...
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Re: The Aging Stress Response and Its Implication for AMD Pathogenesis 2022.10.09해당카페글 미리보기
arrows point at the RPE layer. Although AMD pathogenesis is not fully known, many factors, both genetic/epigenetic and environmental/lifestyle, may be involved [95]. Mechanisms and factors of AMD pathogenesis are described in many...
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Age-related alterations and senescence of mesenchymal stromal cells 2022.10.08해당카페글 미리보기
some point fails to be resolved, and immune responses to the perceived damage, which persists as a state of chronic inflammation (Sokolove and Lepus, 2013). Recently, Josephson et al. showed that rather than actual chronological aging...
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Cellular Senescence in Brain Aging 2022.10.07해당카페글 미리보기
reductionist point of view, we age as our cells senesce (Campisi, 2001). Interestingly, the process of cellular senescence cannot be reduced to a simple loss of cell function and death. Senescent cells are alive, resistant to apoptosis...
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Disea 2022.10.02해당카페글 미리보기
biosynthetic intermediate), and increases mROS production (signaling). Therefore, interpretation of experimental results from these approaches can be difficult and need to be taken in the context of the whole system. There is...
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Polypropylene 2022.10.02해당카페글 미리보기
melting point of 130 °C (266 °F).[11] Below 0 °C, PP becomes brittle.[12] The thermal expansion of PP is very large, but somewhat less than that of polyethylene.[12] Chemical properties[edit] Polypropylene at room temperature is...
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The Words of Sun Myung Moon - January 1, 1972 - 1 2022.09.26해당카페글 미리보기
an intermediate stage. This organization was made possible by the cooperation among Korea, Japan and Taiwan. It must become one with the established churches, creating an Abel sphere centered upon the nation. After this year, I must...
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러시아 부분 동원령.. 2022.09.21해당카페글 미리보기
that point is reached. That is why Dima concludes that: "We can say that today was the best ever [..] day for the Russians in the territory of Ukraine."..... 이런 비유는 으시시합니다.... It is now probably assured that they will be...
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우크라인의 인천상륙작전 성공?? 2022.09.12해당카페글 미리보기
that point is reached. That is why Dima concludes that: "We can say that today was the best ever [..] day for the Russians in the territory of Ukraine."..... 이런 비유는 으시시합니다.... It is now probably assured that they will be...
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Unification Thought - 10 - Logic 2022.09.01해당카페글 미리보기
starting point of the creation of the universe. Hegel first explained the development of Being-Nothing-Becoming in the world of Idea. Since Being as it is has no development, lie thought of Nothing as something to be opposed to Being...