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#3불치병치료이야기("태공의 부활") 2020.12.14해당카페글 미리보기
되돌리는데 관여하는 핵심전사인자 5개(CDX2, ELF3, HNF4G, PPARG, VDR)를 규명하였습니다. 또한, 후성유전학적 조절인자(epigenetic regulator)라 할 수 있는 ‘SETDB1’ 역시 발견하였으며, 'SETDB1'이 활성화됨에 따라 핵심전사인자들의 발현이 차단...
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공부할 자료- Transmissible RNA Pathway in Honey Bees 2020.11.28해당카페글 미리보기
1970). In other words, nutritional differences trigger one genome to direct two distinct phenotypic outputs in honey bees. Epigenetic regulation has been shown to play a role in the honey bee’s caste differentiation (Kucharski et al...
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■ 노화 세포를 젊은 세포로 되돌리는 기술 개발 2020.11.27해당카페글 미리보기
역분화시키는 4개의 'OSKM (Oct4, Sox2, Klf4, c-Myc) 야마나카 전사 인자'를 일시적으로 발현, 후성 유전학적 리모델링(epigenetic remodeling)을 일으킴으로써 노화된 세포를 젊은 상태로 되돌리는 부분적 역분화(partial reprogramming)를 택하고 있다...
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Re: Melanoma—Time to fast or time to feast? An interplay between PPARs, met 2020.11.25해당카페글 미리보기
hydroxylases) and the above‐mentioned arginine transmethylation. Acetylation and demethylation, responsible for epigenetic regulation, are the most important histone modifications that control T‐cell fate.86 Awareness about these facts...
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Tumor-associated macrophages in tumor metastasis: biological roles and clin 2020.11.22해당카페글 미리보기
and its regulatory networks. Polarization of TAMs is regulated by multiple microenvironmental cytokines, growth factors, epigenetic regulators, and other signals derived from tumor and stromal cells. Two types of macrophages (M1/M2...
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케톤체(BHB, 베타-하이드로뷰티레이트) 대하여 - 2019 리뷰논문 2020.11.21해당카페글 미리보기
to have cellular signaling functions. These signaling functions of BHB broadly link the outside environment to epigenetic gene regulation and cellular function, and their actions may be relevant to a variety of human diseases as well as...
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Re: 수명연장 보충제에 대한 2017 리뷰논문 2020.11.20해당카페글 미리보기
was gained of the fundamental molecular and cellular processes underlying aging, including genomic instability, epigenetic deregulation, loss of proteostasis, mitochondrial dysfunction, cellular senescence, exhaustion of stem cells...
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Anti-senescence compounds: A potential nutraceutical approach to healthy ag 2020.11.20해당카페글 미리보기
al., 2013). Increasing data support a role for silent information regulators (SIRTs/sirtuins), a class of nutrient-sensitive epigenetic regulators, in promoting mammalian health, modulating cellular senescence and lifespan. SIRT1 is a...
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Re: 노화세포제거 약물의 발견부터 발달까지. 2020.11.19해당카페글 미리보기
factor cascades enforce replicative arrest and cause altered expression of hundreds of genes as well as epigenetic changes in DNA. Cellular senescence takes longer to become established than other cell fates, such as replication...
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Re: Metformin as Anti-Aging Therapy: Is It for Everyone? 2020년 리뷰논문 2020.11.17해당카페글 미리보기
action on lysosomal ions contributes to the prolongevity and health-promoting effects of the drug. Go to: Epigenetic Modulation by Metformin Advances in machine learning have enabled next-generation studies of drug-target interactions...