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Re: Metformin as Anti-Aging Therapy: Is It for Everyone? 2020년 리뷰논문 2020.11.17해당카페글 미리보기
lactic acidosis that were far greater with sister-compounds buformin and phenformin (the latter two are no longer in clinical use). Metformin went into use in the USA in 1995, boosting its use and stimulating research targeted at...
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Re: Exercise Mimetics(운동효과약물): Impact on Health and Performance 2020.11.09해당카페글 미리보기
lactic acidosis (Luft et al., 1978). Increased cardiac risk and gastrointestinal disturbance are also major concerns for recurrent use of AMPK activators (Boussageon et al., 2012). GW501516, a potent and stable PPARδ agonist, showed...
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Re: Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer 2020.10.14해당카페글 미리보기
such metabolic symbiosis has been confirmed in vivo by recent isotope tracer measurements, showing a rapid exchange of lactate between the tumor and circulation in several cancer models (39, 47). Interestingly, the MCT-mediating lactate...
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Effects of glycosylated hemoglobin levels on neutrophilic phagocytic functi 2020.10.11해당카페글 미리보기
of acidosis and marked malnutrition. Similarly, Van Oss (1971) reported that high serum glucose levels (200, 400 and 800 mg/100 ml) significantly decreases the neutrophilic phagocytosis of Staphylococcus epidermidis, Staphylococcus...
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Re:메트포민의 항암 기전 - 2018년 리뷰논문 2020.10.09해당카페글 미리보기
prevent metabolic compensatory mechanisms will be required to effectively manage metastatic disease. MetforminA Drug With A Long History Metformin was first discovered in the 1920s by a French physician from a plant called Goat's Rue (1...
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β-hydroxybutyrate, poly-β-hydroxybutyrate and inorganic polyphosphate 역할 2020.10.08해당카페글 미리보기
of acidosis or ketosis may be important factors in these cardiovascular complications. However, it is important to emphasize that in 17 patients who actually benefited from ketogenic diet (these patients were weaned off anticonvulsants...
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타우린이 보이는 놀라운 효과들 - 평생 매일 먹는 보충제로 선정 2020.09.30해당카페글 미리보기
the treatment of the mitochondrial disease, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and offers a new approach for the treatment of metabolic diseases, such as diabetes, and inflammatory diseases...
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Re: 암환자의 단기기억장애 치료 - 티아민 1000mg 오전 오후 복용 2020.09.27해당카페글 미리보기
increased metabolic demands and energy requirements, particularly when thiamine supplementation is not administered in proportion to the increase. In cancer patients, clinical examples might include states of infection [6], sepsis [9...
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Re:Thiamine Deficiency in Tropical Pediatrics: New Insights into a Neglecte 2020.09.27해당카페글 미리보기
53. doi:10.3945/an.114.007526 CrossRef Full Text | Google Scholar 12. Klein M, Weksler N, Gurman GM. Fatal metabolic acidosis caused by thiamine deficiency. J Emerg Med (2004) 26(3):301–3. doi:10.1016/j.jemermed.2003.11.014 PubMed...
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Mechanism and Health Effects of Heavy Metal Toxicity in Humans - 2018리뷰 2020.09.27해당카페글 미리보기
of clinical symptoms and is characterized by hypotension, shocks, lethargy, hepatic necrosis, tachycardia, metabolic acidosis and may sometimes lead to death [93]. The fourth and final stage usually occurs within 2–6 weeks of iron...