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본태성 고혈압의 유병률 -지안 파올로 로시(Gian Paolo Rossi), 2024.07.07해당카페글 미리보기
albeit not generally known with precision for many forms, is much higher than usually held and the misbelief that secondary hypertension is exceptional is just due to the absence of systematic search of the causes of hypertension...
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면역세포의 노화. 2023년 nature review 2024.07.06해당카페글 미리보기
and noncoding RNAs, is widely identified as a hallmark of aging, increasing autoimmune disorders, and particularly the...risk in elderly individuals. However, the underlying mechanisms responsible for these alterations are not yet known...
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Re: T 세포로 보는 자가면역으로 전환하는 시점 탐구!! 2023년 Nature 2024.07.06해당카페글 미리보기
but not CD8+ thymocytes, and serves as a master regulator for CD4 lineage commitment.58,59 Mice with Thpok depletion or a missense mutation lack CD4+ T cells,58,60,61,62,63 whereas ectopic expression of Thpok strongly drives DP...
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만성염증 --> 자가면역으로 전환하는 시점 탐구!! 2024.07.06해당카페글 미리보기
may not necessarily manifest systemically, and may be restricted to the site of autoimmune insult. Some studies have reported an age-related defect in NOD Treg function [11], while others were unable to detect any major deficiency [12...
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스트레스 반응이 어떻게 자가면역 쇼그렌증후군을 일으키는가? 2024.07.05해당카페글 미리보기
far identified, is induction of ER stress [64]. During the last 20 years, in the attempt to understand the salivary gland lesion in SS, histopathology and cell culture studies had shown that MHC and costimulatory molecules were...
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Re: 쇼그렌 증후군 최신약물 탐구 노력의 실패!! 2024.07.05해당카페글 미리보기
is not only contributed by non-Hodgkin lymphoma (NHL) but also by other hematological malignancies and solid tumors [Citation6]. Being a chronic immunological condition, SS brings long-term malaise and requests years of regular health...
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Guantanamo Bay Naval Base, Cuba 2024.07.04해당카페글 미리보기
but not the naval base” ~ JAN 30, 2015~ Geography The Naval Base occupies three main geographical sections: Leeward Point, Windward Point, and Guantánamo Bay. Guantánamo Bay physically divides the Naval Station into sections. The bay...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
do not constitutively express pro-IL-1β.60,61 In addition, emerging evidence suggests that signal 1 may also prime NLRP3 via post-translational mechanisms, such as NLRP3 deubiquitination.62,63 Typical inducers of signal 1 include...
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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
first identified the nuclear factor in B lymphocytes binding to the kappa enhancer of the gene encoding the κ light- chain of immunoglobulin by electrophoretic migration assays of end-labeled DNA fragments and named it nuclear factor...
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Re: 활성산소(산화물질)을 생성하는 기관은? 미토콘드리아, 페록시좀 2024.07.03해당카페글 미리보기
The Redox metabolism of Mitochondria - Antioxidant Systems), peroxisomal thioredoxins and glutaredoxins have not yet been identified in mammals. Finally, it should be noted that—although peroxisomes contain (i) enzymes that can produce...