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Re:Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies 2020.02.17해당카페글 미리보기
cell adhesion and migration, and epithelial–mesenchymal transition [32–35]. All these activities of telomerase are thought to contribute significantly to the process of oncogenesis. TL maintenance by telomerase is a complex multistep...
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Re:Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases 2020.02.16해당카페글 미리보기
junctional adhesion molecules (JAM),17tricellulin,18 and angulins.19 These transmembrane proteins interact between themselves (both homophilic and heterophilic interactions) and with intracellular scaffolding proteins, including zonula...
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암세포 미세환경(Targeting Tumor Microenvironment) for Cancer Therapy 2019 리뷰논문 2020.02.15해당카페글 미리보기
the promoter regions of over 100 genes involved in hypoxia response [19,44]. This response to low oxygen pressure levels includes regulation of genes involved in glucose metabolism, cell proliferation, angiogenesis, macrophage...
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Re:TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis 2020.02.14해당카페글 미리보기
mediates EMT. TGF-β is a strong promoter of EMT, which is characterized by a loss of epithelial and gain of mesenchymal...cells remodel into highly migratory mesenchymal cells, followed by decreased adhesion ... Increasing data have...
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Re:Re:Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review) 2020.02.14해당카페글 미리보기
junctional adhesion molecule 1/A, or zonula occludens-1 (50). The third group is a typical helix-loop-helix family of TFs, including TWIST1, TWIST2, inhibitor of differentiation proteins (ID) and E12/E47. These factors induce EMT alone...
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Re:Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer 2020.02.13해당카페글 미리보기
cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types. EMT is essential for numerous developmental processes...
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Re:The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy 2020.02.10해당카페글 미리보기
bFGF induced hyperphosphorylation of p38 MAPK on endothelial cells (52, 53). Promoter histone modifications were further shown to mediate tumor endothelial cell anergy, as adhesion molecule expression was shown to be epigenetically...
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Re:The Roles of Autophagy in Cancer 2020.02.10해당카페글 미리보기
cell adhesion and associations with autophagy. One study suggested that defects of autophagy enhance EMT by stabilizing TWIST1 [150]. In colorectal cancer stem-cells, the maintenance of pluripotency in CSCs requires complex responses...
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Selected Office Based Anticancer Treatment Strategies - 최신 식이요법 암치료법 2020.02.10해당카페글 미리보기
cell adhesion molecules and growth factors that promote cellular homing and metastasis. It also affords important antioxidant protection and serves as an immunomodulatory for both the innate and adaptive arms of the immune system [3–7...
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익힌 마늘 성분(휘발성 황화합물 DATS)의 항암효과 2020.01.30해당카페글 미리보기
increased adhesion [72]. Regulation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway may also contribute to migration and invasion of cancer cells as ectopic expression of STAT3 in LNCaP cells...