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Re: Intercellular mitochondrial transfer as a means of tissue revitalizatio 2022.10.26해당카페글 미리보기
subsequent fusion with healthy mitochondria in recipient macrophages.107 Cancer cells can also export their damaged mitochondria to normal cells within their TME to adapt to different disruptions, thus favoring tumor progression. Wang et...
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Re: Mitochondrial Fission, Fusion, and Stress - 사이언스 2016년 논문 2022.10.22해당카페글 미리보기
cytochrome c by membrane hemifusion intermediates that are formed during mitochondrial fission (43). Intriguingly, Bcl-2...members also participate in mitochondrial fission and fusion in nonapoptotic cells (44). Thus, mitochondrial...
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Re: Mitochondrial dysfunction in cell senescence and aging 2022.10.22해당카페글 미리보기
involves fusion proteins such as mitofusin 1 and 2 (Mfn1/2) and optic atrophy protein 1 (OPA1). Mitochondrial fission produces new mitochondria by recruitment of Drp1 protein to the surface of mitochondria by receptors like FIS1, Mff...
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Cellular senescence: all roads lead to mitochondria 2022.10.22해당카페글 미리보기
Fission, Fusion, and Stress Fig. 1. Mitochondria in senescent cells exhibit several changes in terms of function, structure, and dynamics. Senescent cells show increased mitochondrial protein leak and decreased mitochondrial membrane...
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Mitochondrial control of inflammation - 2022년 nature reviews 2022.10.20해당카페글 미리보기
cytochrome c, hence compromising the ability of mitochondria to preserve metabolic homeostasis and ionic equilibrium across the IMM45. In this setting, BAX–BAK1 pores in the OMM enable the extrusion of the IMM into the cytosol (driven...
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Spider silk 2022.10.09해당카페글 미리보기
support cell proliferation. Suggested applications include skin transplants, and supportive membranes in organ-on-a-chip.[80] These spider silk nanomembranes have also been used to create a static in-vitro model of a blood vessel.[81...
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Re: Protein clearance strategies for disease intervention 2022.10.09해당카페글 미리보기
lines, C9orf72‐associated cases exhibit neuropathological changes characterized by abundant protein inclusions (Cooper-Knock et al. 2012), indicating a link with proteostasis deficits. Besides neurodegenerative diseases, other disorders...
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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
The fusion is dependent on SNARE proteins VAMP8 and Vti1B29. In microautophagy, a pathway characterized to a much lesser extent, small components of the cytoplasm are engulfed directly by the lysosome membrane14. In CMA, particular...
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Re: The Aging Stress Response and Its Implication for AMD Pathogenesis 2022.10.09해당카페글 미리보기
by fusion (mitofusin 1 (MFN1), MFN2 and mitochondrial dynamin-like 120 kDa protein (OPA1)) and fission (dynamin 1-like protein (DNM1L) and mitochondrial fission 1 protein (FIS1)) proteins [45,46]. Damaged mitochondrial components can be...
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Re:Epigenetic Regulation of Genomic Stability by Vitamin C 2022.10.09해당카페글 미리보기
chromosomal fusion (Yang et al., 2016). Genomic instability has also been observed in Tet2/3 double knockout hematopoietic stem and progenitor cells (HSPCs) and immature myeloid cells, which show impairment of DNA repair responses, lower...