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The Ramen Lord 2024.02.16해당카페글 미리보기
at specific intervals five more times before it’s cut into those familiar long strands. And that’s just the noodles for his miso ramen; for his soupless ramen, he uses a thicker noodle with an entirely different, but also painstakingly...
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Mitochondrial TCA cycle metabolites control physiology and disease 2024.02.15해당카페글 미리보기
of specific transcription factors and histone marks that ultimately dictate cellular functions by regulating gene expression. α-ketoglutarate α-KG, also known as 2-oxoglutarate, is an obligatory co-substrate for 2-oxoglutarate...
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미토콘드리아 아미노산 합성, 대사.. 암.. 2024.02.15해당카페글 미리보기
Ubiquitin Specific Peptidase 1 (USP 1) through the GCN2-eIF2a pathway and inhibit the degradation of BCAT2 by deubiquitination of the K299 site of BCAT2. This process is inhibited during the BCAAs deprivation. cAMP-responsive Elin...
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Re: The role of cell death in SARS-CoV-2 infection 2024.02.14해당카페글 미리보기
TM2 domain in M protein with PH domains in PDK1, thus reducing the substrate activities, which include apoptosis signal-regulating kinase (ASK) and forkhead transcription factor (FKHRL1).23 The reduced FKHRL1 phosphorylation level...
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침입한 바이러스에 감염된 세포의 운명은? 2024.02.14해당카페글 미리보기
말단 도메인을 분리합니다(GSDMD N터름, GSDMD C터름). GSDMD 막 기공 형성은 발열성 세포 사멸의 메커니즘을 구성합니다. 2.1. Apoptosis Apoptosis is a naturally occurring process that plays a distinct role in morphological and biochemical...
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Re: Autophagy in healthy aging and disease 2021년 nature review 2024.02.05해당카페글 미리보기
binding domain-containing protein 1 (STBD1) may allow cells to physically link glycogen to GABARAPL1, facilitating the transport of glycogen to lysosomes for degradation (Fig. 1a, pathway (3))94. In parallel to glycophagy, other pathways...
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Re: Role of immune cells in the removal of deleterious senescent cells 2024.02.05해당카페글 미리보기
in specific pathologies. Systemic lupus erythmatosus (SLE): defects in multiple steps of efferocytosis have been recognized in SLE. High levels of autoantibodies against scavenger receptor class F member 1 (SCARF1) (a phosphatidylserine...
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The Beneficial and Adverse Effects of Autophagic Response to Caloric Restri 2024.02.03해당카페글 미리보기
be specific, the exposure of normal cells to calorie restriction leads to the consumption of energy (ATP) for maintenance and regeneration purposes rather than proliferation. In tumor cells, the activation of several oncogenes such as...
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Gluten-Specific Peptidases, Proline-Specific Peptidases(PSPs) 글루텐 분해효소 2024.02.03해당카페글 미리보기
highly specific peptide substrates Z-Ala-Ala-Gln-pNA, Glp-Phe-Gln-pNA, and Glp-Phe-Gln-AMC, where Z is benzyloxycarbonyl, Glp—pyroglutamyl, pNa—p-nitroanilide, and AMC—4-amino-7-methylcoumaride [29,30,31]. Post-glutamine cleaving...
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Re: Cathepsin B in programmed cell death machinery 2024.02.02해당카페글 미리보기
as apoptosis stimulation fragment ligand, caspases are activated by cleavage at specific aspartic residues, resulting in the removal of an inhibitory N-terminal domain and the production of a large and a small subunit. Caspase-8 and 10...