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산화질소 탐구!! 산소와 산화질소의 관계... 2024.07.17해당카페글 미리보기
Eq. (7) (Fig. 1B) [35], [36], [37]. (6)NO−2+HbFe2++H+→•NO+HbFe3++OH− (7)XO+NO−2+e-→•NO Unlike NOS-mediated •NO synthesis which requires O2, the generation of •NO by the above reactions is enhanced at low O2. They are thought...
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Re: 면역 조절기능에서 대식세포의 역할 2023년 nature review 2024.07.16해당카페글 미리보기
roles of autophagy and aging in regulating macrophage functions. Moreover, we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis. Lastly, we discussed targeted macrophage therapy...
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Re: 활성산소 --> Cell senescence --> 노화 탐구!! 2024.07.16해당카페글 미리보기
shows ROS as signaling molecules, besides metabolic byproducts. They act in a myriad of pathways and networks, mediated by hormones, which ranges from protein phosphorylation to transport systems, for example. ROS do not influence single...
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Re: 활성산소의 DNA 손상에 대한 탐구!! 2024.07.16해당카페글 미리보기
of related pathways including Homologous Recombination (HR), Non-Homologous End Joining (NHEJ), Microhomology Mediated End Joining (MMEJ) and the Fanconi Anaemia (FA) repair complex [3]. Amongst these, the influence of ROS on the DSB...
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Re: Re: 활성산소의 지질(lipid) 손상에 대한 탐구!! 2024.07.16해당카페글 미리보기
glutathione disulfide (GSSG) to glutathione (GSH), a cosubstrate for the GSH-Pxs. The reaction sequence of TrxR-mediated reduction of protein disulfides has been reviewed [18]. The thioredoxin (Trx) and glutathione (GSH) systems could be...
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Re: 활성산소의 단백질 손상 vs 유익함에 대한 탐구!! 2024.07.16해당카페글 미리보기
damage. Methods Enzymol. 2000;319:428–436. [PubMed] [Google Scholar] 8. Stadtman ER, Levine RL. Free radical-mediated oxidation of free amino acids and amino acid residues in proteins. Amino Acids. 2003;25:207–218. [PubMed] [Google...
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Re: 활성산소 연구의 히스토리.. 2024.07.16해당카페글 미리보기
two different enzymes namely disulfide reductases and methionine sulfoxide reductases respectively [91–94]. The ROS mediated attack of different amino acids results in the formation of different oxidation products such as, tryptophan...
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면역반응의 산화, 환원 생리학!! 2022년 nature review 2024.07.15해당카페글 미리보기
83, 84]. These parameters are discussed below commencing with the Toll-like Receptor (TLR) and proinflammatory cytokine-mediated reprogramming of the lipidome [85]. The synthesis of lipids is a key component in membrane remodeling. In M1...
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Re: 항산화 치료법으로 질환을 치료하는 관점.. 2021년 nature review 2024.07.15해당카페글 미리보기
X− may be Cl−, Br− or even SCN− (ref.281). They play a major role in tissue damage associated with phagocyte-mediated inflammation. 여기서 X-는 Cl-, Br- 또는 SCN-일 수도 있습니다(참조.281). 이들은 식세포 매개 염증과 관련된 조직 손상...
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Re: 위장의 염증을 보호하는 산화질소 탐구... 2024.07.15해당카페글 미리보기
NO and COX derived prostaglandins share similarities in various gastrointestinal functions. NO and prostaglandin mediated mechanisms of mucosal defense also exhibit a degree of cooperation. Suppression of one arm can lead to a...