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Re:The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer 2020.01.29해당카페글 미리보기
6 promoter single nucleotide polymorphism (SNP) 174 G > C (rs1800795), where IL-6 was upregulated in the samples with the expression of 174 G allele and downregulated in the samples with 174C allele [52]. Another study implied that GG...
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Re:The role of the insulin-like growth factor-1 system in breast cancer 2020.01.28해당카페글 미리보기
enhanced promoter activity, indicating a regulation in cis [40,64]. Other SNPs of both IGFBP1 and IGFBP3 have also been associated with plasma IGFBP3 levels [36,64]. Additionally, a Mendelian randomization study showed that the a allele...
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Re:Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma 2020.01.27해당카페글 미리보기
intercellular adhesion though binding to various catenins (including β-catenin), and loss of E-cadherin is associated with an increased tendency for tumor metastasis [174]. Anti-metastatic effects of curcumin have also been demonstrated...
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Re:Hallmarks of Cancer: The Next Generation 2020.01.05해당카페글 미리보기
by promoter methylation ( Jiang and Liu, 2009 , Yuan and Cantley, 2008 ). Yet another example involves the mTOR kinase, a coordinator of cell growth and metabolism that lies both upstream and downstream of the PI3K pathway. In the...
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Re:암세포 전이에 관한 review 논문!! 2019.12.29해당카페글 미리보기
focal adhesion proteins [45]. Besides migration and invasion, PI3K/Akt/mTOR signaling supports cell survival. Akt inactivates different pro-apoptotic factors like Bad and procaspase-9, and inhibits the expression of pro-apoptotic genes...
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Re:The hypoxic tumour microenvironment - 2018년 nature 논문 읽어야 2019.12.25해당카페글 미리보기
focal adhesion formation creates a mechanism for the metastatic spread of cancer cells. Blood vessels Vascularisation is one of the main outcomes of HIF signalling. HIF-1α and HIF-2α inactivation led to developmental lethality in mice...
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Re:The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy 2019.12.25해당카페글 미리보기
1a promoter was shown to be responsive to certain NFKB subunits.39 The HIF pathway is required during physiological processes and is implicated in cancer biology by regulating hundreds of genes.47–49 This master regulator facilitates...
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저산소 환경과 암세포 발생, 성장의 관계 - 논문 4편 꼭 읽어야 2019.12.25해당카페글 미리보기
the promoter of murine Oct4, which is a stem cell regulatory protein; this is not the case for HIF-1α.39 HIF-2αmay have a specific function in glioblastoma stem cells: it was shown to be selectively expressed in the CD133...
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Re: 글루타치온의 항암기전 2019.09.28해당카페글 미리보기
The promoter regions encoding GSTs and γ GCL possess binding sites for transcriptional regulators such as NF-kB, AP-1, AP-2, and the Nrf2/Kelch-like ECH-associated protein 1 (Keap1) system. After exposure to oxidative stimuli, Nrf2...
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Arginine and the metabolic regulation of nitric oxide synthesis in cancer 2019.09.11해당카페글 미리보기
the adhesion molecule VCAM-1, which is important for T-cell extravasation. Additionally, only co-transfer of CD8+ T cells with wild-type macrophages, but not with Nos2−/− macrophages, yielded T-cell homing to the tumor, and...