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Re: ER stress - oxidative stress, inflammation의 이해 2023.08.24해당카페글 미리보기
mitochondrial function, besides causing an enhancement in endoplasmic reticulum (ER) stress, neuroinflammation and synaptic loss. As accumulation of misfolded proteins hampers normal neuronal functions, it triggers ER stress, which leads...
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circuitry / sulfate / 2023.08.21해당카페글 미리보기
can also form structures known as “perineuronal nets,” which wrap around individual neurons and stabilize the synaptic connections between them. One way a GAG’s function can be changed is through sulfation motifs, or patterns of...
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Re: BDNF를 자극하는 한약재들!! 2023.08.14해당카페글 미리보기
biological functions. The proBDNF binds with high-affinity p75NTR leading to apoptosis, neurite retraction, and synaptic weakening and facilitating long-term depression, whereas mBDNF binds with TrkB receptors promoting cell survival...
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Re: Autophagy in axonal and dendritic degeneration 2023.08.14해당카페글 미리보기
in which molecules including proteins are synthesized, delivered, and degraded for their dynamic functions in synaptic growth and activity. Upon specific stimuli, the axons and dendrites of cultured neurons exhibit features of...
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Re: Mechanisms of neuronal homeostasis: autophagy in the axon 2023.08.14해당카페글 미리보기
by mTOR-inhibition increased the number of autophagosomes at presynaptic sites, and also decreased the number of synaptic vesicles (Hernandez et al., 2012). Thus, autophagy modulates neurotransmission, by potentially sequestering...
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Re: 신경, 축삭의 자가포식이 안되면 치매, 파킨슨, 루게릭병은 악화!! 2023.08.14해당카페글 미리보기
as fully competent degradative organelles. Misregulation of neuronal autophagy leads to axonal degeneration and synaptic destabilization, and has been implicated in neurodegenerative diseases including Alzheimer’s disease, Parkinson’s...
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알츠하이머 치매 치료법을 위한 comprehensive review 논문... molecules 2023.08.14해당카페글 미리보기
to (2) negative lesions (due to losses), that are characterized by large atrophy due to a neural, neuropil, and synaptic loss. Besides, other factors can cause neurodegeneration such as neuroinflammation, oxidative stress, and injury of...
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Re: NMDAR 길항제 - 치매약 메만틴의 효과와 부작용 논문 2023.08.14해당카페글 미리보기
are abundant and ubiquitously distributed throughout the central nervous system (CNS), playing a critical role in synaptic plasticity and the cellular processes that underlie learning and memory [37]. Long-term potentiation (LTP) is a...
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Acetylcholinesterase Inhibitors - 치매약 도네피질의 부작용 논문 2023.08.14해당카페글 미리보기
dependent pump that acidifies the vesicle [7]. During neurotransmission, ACh is released from the nerve into the synaptic cleft and binds to ACh receptors (nicotinic and muscarinic) on the post-synaptic membrane, relaying the signal from...
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루게릭 병 발생 기전 - autophagy and/or mitophagy 2023.08.13해당카페글 미리보기
2012; Neisch et al., 2017). Autophagosomes form in a stepwise manner in the growth cone of neurons in culture and at synaptic sites such as the neuromuscular junction in vivo (Neisch et al., 2017; Stavoe et al., 2016). Once formed...