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Mitochondrial TCA cycle metabolites control physiology and disease 2024.02.15해당카페글 미리보기
levels, resulting in stimulation of the regulatory enzymes of the TCA cycle. Abundant acetyl-CoA inhibits PDH but activates pyruvate carboxylase to increase the formation of OAA from pyruvate and thus pair the levels of the two...
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미토콘드리아 아미노산 합성, 대사.. 암.. 2024.02.15해당카페글 미리보기
insensitive complex 2 (mTORC2). mTORC1 is activated by glutamine (Gln), arginine (Arg), and Leucine (Leu), and activates protein synthesis by phosphorylation of eIF4E binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6...
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Re: The role of cell death in SARS-CoV-2 infection 2024.02.14해당카페글 미리보기
11,12,13,14 Middle East respiratory syndrome coronavirus (MERS-CoV) induces cell death of different cell types and activates multiple cell death pathways.14 Recently, with the outbreak of novel COVID-19, researchers have found that SARS...
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침입한 바이러스에 감염된 세포의 운명은? 2024.02.14해당카페글 미리보기
triggers the release of Cyt c, which forms apoptosomes with Apaf-1 and caspase-9 during apoptosis. Dimerization activates caspases in apoptosomes, resulting in caspase signaling. Through the mitochondrion, apoptosis-inducing factor and...
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Re: Autophagy in healthy aging and disease 2021년 nature review 2024.02.05해당카페글 미리보기
complex, which is tightly regulated by AMPK and mTOR, which act as an activator and inhibitor, respectively. AMPK activates ULK1 through phosphorylation. The ULK1 complex, composed of FIP200, ATG13 and ATG101, stimulates the class III...
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Cellular senescence and senolytics: the path to the clinic 2022 natur 리뷰 2024.02.05해당카페글 미리보기
The SASP is a key feature of cellular senescence. Cellular stressors induce DNA damage response signaling, which activates key transcription factors and pathways including NF-κB, CCAAT/enhancer binding protein-β (C/EBPβ), GATA binding...
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The Beneficial and Adverse Effects of Autophagic Response to Caloric Restri 2024.02.03해당카페글 미리보기
ATP forces the cells toward necrotic changes rather than apoptosis and/or autophagic death [84]. Rapid ATP depletion activates excessive autophagy flux, which exceeds the degradation capacity of lysosomes, resulting in the accumulation...
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Re: Cathepsin B in programmed cell death machinery 2024.02.02해당카페글 미리보기
release cytochrome c. The binding of cytochrome c to APAF1 promotes apoptosome assembly, which recruits and activates caspase 9. Notably, leakage of CatB from the lysosome involves in TFAM degradation and Bid truncation, resulting in...
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Re: 병든 세포의 제거와 수리, 리소좀 2024.02.02해당카페글 미리보기
of axis inhibition protein 1 (AXIN)-live kinase B1 (LKB1) complex with v-ATPase and Ragulator, which then activates AMPK signaling (Fig. 2).48,49,50 Concurrently, AXIN cause the dissociation and inactivation of mTORC1 by interfering with...
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Autophagy genes in biology and disease 2024.02.01해당카페글 미리보기
interactions between Atg1, Atg13 and Atg17 (ref. 13), and provides an environment that intermolecularly auto-activates the Atg1 kinase14. Thus, ULK/Atg1 complex assembly is a key step in initiating macroautophagy. 스캐폴드 단백질 FIP200...