카페검색 본문
카페글 본문
-
Re: The Hallmarks of Aging 2022.10.26해당카페글 미리보기
and mortality risk, particularly at younger ages (Boonekamp et al., 2013). Overview Normal aging is accompanied by telomere attrition in mammals. Moreover, pathological telomere dysfunction accelerates aging in mice and humans, while...
-
Hypertension vs. Chai-Hu-Jia-Long-Gu-Mu-Li-Tang 2022.10.24해당카페글 미리보기
followed by Ginseng Radix or Codonopsis Pilosulae Radix and Zingiberis Rhizoma Recens in five studies (71.4%) each. The administration duration varied from 2 weeks to 7 months, with 4 weeks being the most (Table 2). 3.3. Risk of Bias...
-
Re: Mitochondrial dysfunction in cell senescence and aging 2022.10.22해당카페글 미리보기
characterized by high levels of DNA and specifically telomere damage, a persistent DNA damage response, an activated SASP, shifts in the NAD+/NADH ratio, activation of innate immune responses, and activation of antiapoptotic mechanisms...
-
1962년 - 쿠바 미사일 위기 시 소련 해군의 잠수함 작전 2022.10.20해당카페글 미리보기
discovered by the anti-submarine forces. The U.S. Navy had an existing tactical protocol against diesel submarines called “hunt to exhaustion,” analogous to the British tactics of fighting against the German submarine fleet during...
-
Re: The chromatin landscape of cellular senescence 2022.10.15해당카페글 미리보기
starvation in cell culture). Replicative senescence An irreversible arrest to the cell-cycle that is caused by telomere attrition due to the accumulation of cell-divisions. Oncogene-induced senescence An arrest to the cell-cycle caused...
-
Gut microbiome and cellular senescence .. aging and disease 2022.10.09해당카페글 미리보기
telomere attrition suggesting that the chronic presence of different stressors can rapidly induce/augment different (oxidative/replicative/oncogenic) senescence programs in cells [59, 60]. Although the development of SC is relatively...
-
Re:Epigenetic Regulation of Genomic Stability by Vitamin C 2022.10.09해당카페글 미리보기
antioxidants by multivitamin supplementation or high vegetable intake is associated with increased telomere length in human studies (Xu et al., 2009; Marcon et al., 2012; Tsoukalas et al., 2019), however, direct evidence that vitamin C...
-
Re: Targeting the molecular & cellular pillars of human aging with exercise 2022.10.08해당카페글 미리보기
Telomere attrition during somatic cell division constitutes another type of age-related chromosomal deterioration and has been linked to chronological aging [[25, 26]]. Telomere shortening increases susceptibility to rampant chromosomal...
-
Age-related alterations and senescence of mesenchymal stromal cells 2022.10.08해당카페글 미리보기
six hub genes and 11 transcription factors related to adherent junctions, DNA damage induced by oxidative stress, telomere attrition, MSC differentiation and epigenetic modulation that were key in aging (Wu et al., 2019). Alves et al...
-
Prosperity knits a man to the World 2022.10.07해당카페글 미리보기
with which we teach them to respond to it] —all this provides admirable opportunities of wearing out a soul by attrition. * [The routine...], [the quiet despair...], [the drabness...] = all this If, on the other hand, the middle years...