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골지 스트레스 반응, 기능부전 2023.08.25해당카페글 미리보기
cells with Brefeldin A activates the CREB3-ARF4 pathway and inhibits the function of ARF proteins. Consequently, the cytoplasmic domains of CREB3 are released from the ER membrane and translocated into the nucleus to upregulate the Golgi...
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Re: ER stress - oxidative stress, inflammation의 이해 2023.08.24해당카페글 미리보기
calcium release [148,149,150,151,152] Parkinson’s disease Loss of dopaminergic nigrostriatal neurons, intra-cytoplasmic Lewy bodies (LBs), intra-axonal Lewy neurites (LNs) Scavenges ROS by inducing the activity of endogenous anti...
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Mitochondrion 2023.08.19해당카페글 미리보기
those from bacteria in size and structure.[120] They closely resemble the bacterial 70S ribosome and not the 80S cytoplasmic ribosomes, which are coded for by nuclear DNA. The endosymbiotic relationship of mitochondria with their host...
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Re: Mechanisms of neuronal homeostasis: autophagy in the axon 2023.08.14해당카페글 미리보기
of the neurite. Many autophagic structures were detected early in formation as they were apparently engulfing cytoplasmic organelles such as dense core vesicles. Furthermore, these early autophagic structures appeared to be continuous...
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Re: 신경, 축삭의 자가포식이 안되면 치매, 파킨슨, 루게릭병은 악화!! 2023.08.14해당카페글 미리보기
and then are rapidly and efficiently transported along the axon toward the soma, driven by the microtubule motor cytoplasmic dynein. Motile autophagosomes mature to autolysosomes in transit by fusing with additional late endosomes...
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알츠하이머 치매 치료법을 위한 comprehensive review 논문... molecules 2023.08.14해당카페글 미리보기
19 and is associated with increasing the risk of AD. ECSIT encodes the adapting protein that functions as a cytoplasmic and signaling protein and is responsible for stabilizing the mitochondrial respiratory complex. Moreover, the adaptor...
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Re: Autophagosome Biogenesis - 2023년 cells 최신논문 2023.08.13해당카페글 미리보기
hereafter referred to as autophagy) is an evolutionarily conserved mechanism for the degradation of cytoplasmic material in lysosomes [1,2]. This process is activated under conditions of cellular stress or nutrient deprivation in...
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루게릭 병 발생 기전 - autophagy and/or mitophagy 2023.08.13해당카페글 미리보기
2016). Once formed, distal autophagosomes are rapidly transported toward the soma via the microtubule-based motor cytoplasmic dynein and its activator dynactin (Figure 1; (Maday et al., 2012; Neisch et al., 2017)). Of note, a G59S...
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Re: 치매의 원인들 2-3. 인슐린 저항성 --> 치매 2023.08.02해당카페글 미리보기
CTFβ, C99). Subsequent cleavage of CTFβ by γ-secretase results in the formation of an APP intracellular cytoplasmic domain (AICD) and Aβ fragments, both of which are released into the extracellular environment. In the extracellular...
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치매의 원인들 1. 아연 부족(zinc deficiency) 2023.07.30해당카페글 미리보기
and metallothioneins (MTs). ZIP proteins transport extracellular and vesicular zinc into the cytoplasm to increase cytoplasmic zinc levels. Conversely, ZnT proteins excrete or remove intracellular zinc by vesicular uptake of zinc [73...