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Re: ER stress-induced cell death mechanisms 2020.08.22해당카페글 미리보기
family death receptors activates caspase-8, which targets a limited number of substrates including Bap31, an integral membrane protein of the ER. The p20 caspase cleavage fragment of Bap31 can direct pro-apoptotic signals between the ER...
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Re:Re:비타민 D의 만성통증 메커니즘 2015년 리뷰논문 2020.06.29해당카페글 미리보기
reactive protein (CRP), IL-1B, and TNF-α [124]. Major depression may be accompanied by systemic immune activation or an inflammatory response with involvement of phagocytic (monocytes, neutrophils) cells, T cell activation, increased...
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Re:Re: 마그네슘과 인간의 건강 2018년 리뷰논문 2020.06.28해당카페글 미리보기
reactive protein (CRP) which is an important marker of inflammation [86–88]. However, it should be taken into account that oxidative stress has several causes starting with unbalanced diet involving not only magnesium but many other...
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Re:Re: 인간의 흔한 질병에서 세포와 연관된 마그네슘의 역할 2020.06.28해당카페글 미리보기
is integral to cellular and systemic human physiology and its ability to function. Yet, this mineral is often overlooked in deference to other cations such as calcium or iron. As the fourth most abundant element in the human body...
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Re:Re:Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses 2020.06.27해당카페글 미리보기
an integral role in the outcome of tissue inflammation. Sepsis is one of the best-studied examples in which apoptosis has clear and profound consequences on the resolution of inflammation. A life-threatening condition responsible for...
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Re:Re: Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise 2020.06.24해당카페글 미리보기
e.g., MG132).67,68 A defining feature for these molecules is that their molecular targets are integral parts of the protein homeostasis network.12,69 Drastically altering the function of the protein synthesis, folding, and clearance...
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Re:Re:Re:Re: Vitamin B12 결핍으로 야기되는 시신경질환 2020.06.22해당카페글 미리보기
brain function, protein metabolism and erythropoiesis. It is mainly obtained from consuming animal products including...and fish and thus lacks in vegan diet. Vit B12 also acts as a cofactor in formation of succinylCoA, an integral part...
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Re:Re:Calcium, ATP, and ROS: a mitochondrial love-hate triangle 2020.06.12해당카페글 미리보기
with protein conformational changes. Ultimately, differences in the subunit composition of the respiratory complexes between tissues may underlie the tissue specificity of Ca2+ effects on ROS generation. Together, Ca2+-mediated events...
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Re:ReVitamin C and immune cell function in inflammation and cancer 2020.06.10해당카페글 미리보기
an integral part of monocyte function is indicated by the demonstrations that HIF-1α or HIF-2α deletion in myeloid cells caused profound impairment of cell aggregation, motility, invasiveness and bacterial killing [84–86], resulting...
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Re:Re:Mito-Nuclear Communication by Mitochondrial Metabolites and Its Regulation by B-Vitamins 2020.05.28해당카페글 미리보기
and decarboxylases (Figure 2) (Depeint et al., 2006a; Braymer and Lill, 2017). FeS clusters are integral parts of many metabolic protein complexes, such as aconitase and ETS complexes, as well as other cellular protein complexes, such...