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배아 복제 연구와 윤리적 문제 2020.11.25해당카페글 미리보기
현상(fusion)이 일어날 수 있다는 사실이다. 두 배아가 결합된 키메라(chimera) 역시 성숙한 개체로 성장할 수 있다. 이러한 생물학적 특성들을 생각할 때 우리가 과연 접합체 시점부터 존재해왔는지 의문을 가질 수 있으며, 배아 실험에 대한 결정적인...
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Fibroblast Growth Factors: Biology, Function, and Application for Tissue Re 2020.11.11해당카페글 미리보기
kinase C (PKC). The physiological relevance of this pathway is not obvious since its disruption does not abolish either mitogenesis [29] or cell differentiation [30]. However, some data indicate that it may be necessary for adhesion, at...
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extrachromosomal circular DNA in cancer pathogenesis and therapeutic resist 2020.11.08해당카페글 미리보기
Myc-containing DMs. Moreover, different sizes and architectures of c-Myc amplicons can coexist within the same cell population, providing evidence of DM heterogeneity. Intriguingly, several fusion genes or circular RNA of plasmacytoma...
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Re: Regulation and function of AMPK in physiology and diseases 2020.11.08해당카페글 미리보기
1c), a transcription factor that promotes the expression of multiple lipogenic enzymes, including ACC1 and FA synthase.49, 50 Excessive accumulation of FAs in cells are stored as TGs. The first committed step in TG synthesis is catalyzed...
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Re: 장수유전자 AMPK를 조절하는 기전 2020.11.08해당카페글 미리보기
lysosomal fusion with autophagosomes. Starvation-induced cardiac autophagy was clearly reduced in mice with cardiac-specific deletion of FoxO1 which also impaired cardiac function in these mice. In addition to the FoxO-mediated...
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최신 면역항암치료법 - 2020년 nature review 2020.11.05해당카페글 미리보기
phospholipase Cγ1 (PLCγ)285. With ample co-stimulation, downstream signalling affects calcium release, the activation...reprogramming essential for activated T cell function286. Following activation, circulating naive T cells...
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Re: Pleiotropic Effects of mTOR and Autophagy During Development and Aging 2020.11.03해당카페글 미리보기
lysosome fusion and endocytic trafficking (Matsunaga et al., 2009; Nakamura et al., 2019). mTOR-Dependent Autophagy in Development and Aging − a Bad Start Compensates for Later A classic inhibitor of mTOR is rapamycin (Sirolimus), which...
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인간의 2번 염색체에서 융합은 결코 일어나지 않았다 : 사람과 원숭이류의 염색체 수 차이에 대한 진화론적 설명의 실패 2020.10.23해당카페글 미리보기
Azzalin, C. M., S. G. Nergadze, and E. Giulotto. 2001. Human intrachromosomal telomeric-like repeats: sequence organization and mechanisms of origin. Chromosoma. 110: 75-82. Ruiz-Herrera, A. et al. 2008. Telomeric repeats far from the...
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Re: 새로운 항암치료 제안 - ONCOLYTIC VIROTHERAPY 2020.10.22해당카페글 미리보기
Balb/c mice85. By 24 hours post intravenous infusion of VSV, vascular perfusion had shut down at the core of the tumors and VSV antigen was detected in the blood vessels. To improve transfer of oncolytic viruses from blood vessel lumen...
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Re: Anticancer mechanisms of cannabinoids 2020.10.22해당카페글 미리보기
CHOP = C/EBP homologous protein; AKT = protein kinase B; TRIB3 = tribbles-homologue 3; mTORC2 = mammalian target of rapamycin complex 2; CDKs = cyclin-dependent kinases; pRb = retinoblastoma protein; CaCMKKβ = calcium/calmodulin...