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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
induce degradation and resynthesis of typical IκB proteins.8 Unlike the rapid and transient activation of IκBα-mediated NF-κB signaling, IκBβ sustainably activates NF-κB and maintains long-term expression of pro-inflammatory...
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만성염증 --> 자가면역 염증으로 진행하는 과정의 중요 인자 NF-κB 탐구!! 2024.07.04해당카페글 미리보기
of NF-κB dimers including p65:p50 dimers. In the non-canonical pathway, NEMO-independent activation of IKKα is mediated by the upstream kinase NIK. IKKα, with NIK, induces phosphorylation and processing of p100 to p52 resulting in the...
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Re: 활성산소(산화물질)을 생성하는 기관은? 미토콘드리아, 페록시좀 2024.07.03해당카페글 미리보기
of the thiol/disulfide redox state in biological systems completely neglect CoA-SH as possible modulator of ROS-mediated signaling events (Hansen et al., 2009). Nevertheless, levels of free CoA-SH are substantial (~10–150 nmol/g tissue...
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주로 지질, 단백질, DNA를 파괴하는 활성산소 탐구!! 2024.07.03해당카페글 미리보기
activity has been intensified in recent years. The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases. 최근...
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Re: 췌장암.. 어떻게 발병하고, 어떻게 진단하고 치료하는가? 최신논문.. 2024.07.02해당카페글 미리보기
include increased immunosuppressive regulatory T cells and myeloid-derived suppressor cells, preventing immune-mediated targeting of cancer cells. In addition, tumor-associated macrophages can promote progression of precancerous lesions...
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Re: 통풍, 요산을 대신하는 항산화제!! 2024.07.02해당카페글 미리보기
to the total plasma antioxidant capacity in humans [33]. At physiological levels, uric acid abrogates the organ injury mediated by activated polymorphonuclear blood and erythrocyte cells, that are well-established producers of free...
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Re: T 세포 교차반응성의 명암... 2024.06.30해당카페글 미리보기
Ab) response against S. pyogenes has been well described (43, 44). Meanwhile, it is clear that also T cell-mediated immune reactions play an important role in RF (40, 44, 45). Three types of protein antigens present on the S. pyogenes...
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음식 이상반응에서 알레르기 교차반응 epitope 탐구!! 2024.06.30해당카페글 미리보기
911KB) Download : Download full-size image Fig 1. Simplified schematic representation of the mechanism of IgE-mediated allergenic cross-reactivity. The process of primary allergic sensitization ultimately leads to the generation of IgE...
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알레르기의 원인 '파발부민' 탐구 2024.06.30해당카페글 미리보기
Intracellular PA was suggested and partially proved to serve as a soluble relaxing factor accelerating the Ca2+-mediated relaxation phase in fast muscles (reviewed in [1]). It is assumed that PA serves as a slow metal buffer in non...
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인간 섬유육종 HT1080에서 D1 및 D2(PLD1/PLD2)의 역할 2024.06.29해당카페글 미리보기
농도의 3차 부탄올을 사용한 전처리는 기포 형성에 영향을 미치지 않았습니다(그림 4하단 패널 및 B). PA의 Butan-1-ol-mediated 고갈은 또한 세포주에 나타나는 bleb의 수를 현저하게 억제하였다(도 4C). 이는 PLD2 매개 세포 출혈이 PA를 통해 이루어...