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Re: Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvir 2020.11.25해당카페글 미리보기
Recently activated CD8+ effector T cells conditioned to use glycolysis are likely most susceptible to sudden loss of exogenous glucose (52, 53), as compensatory endogenous production of glucose through gluconeogenesis or glycogen...
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케톤체(BHB, 베타-하이드로뷰티레이트) 대하여 - 2019 리뷰논문 2020.11.21해당카페글 미리보기
3′ carbon. Increasing oxidation may be a barrier to binding within the hydrophobic channel of the HDAC active site, and as expected, the IC50 of the three compounds for HDAC1 increases with the oxidation state (116, 119). β...
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Re: The impact of dietary protein intake on longevity and metabolic health 2020.11.11해당카페글 미리보기
insufficiency–activated liver nuclear protein1 (NUPR1)-FGF21 axis [37] (Fig. 2a). A LPD also enhances EE by increasing sympathetic flux via β-adrenergic receptor signalling to brown adipose tissue (BAT) with the consequent upregulation...
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Re: Mild hyperbaric oxygen: mechanisms and effects 2020.11.08해당카페글 미리보기
the carbon dioxide concentration in the surrounding region, which in turn, facilitates blood flow in blood vessels [52, 53]. Arthritis Exposure to mild hyperbaric oxygen is effective in decreasing levels of reactive oxygen species...
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Re: 장수유전자 Sirt1을 자극하는 파이토케미칼 - 레스베라트롤, 커큐민, 버버린, 케르세틴, 피세틴 등 2020.11.06해당카페글 미리보기
a carbon bond, which has a β-unsaturated β-diketone fraction (Priyadarsini, 2014). Thousands of years ago, Indians and Chinese described the health-giving effects of this substance, derived from the turmeric plant (Gupta et al., 2014...
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Re: NAD+ and sirtuins in aging/longevity control 2020.11.05해당카페글 미리보기
be activated by c-Myc (Figure 5a). In aged skeletal muscle, this defective TFAM expression causes significant reduction in mitochondrial gene expression, leading to mitochondrial metabolic dysfunction. Decreased SIRT1 activity also...
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Amino acids in cancer 2020.10.30해당카페글 미리보기
CD3-activated TR cells) (Fig. 3c)11,15. As immunometabolic adjuvants to widen therapeutic windows, IDO inhibitors may leverage not only immuno-oncology modalities but also conventional chemotherapy and/or radiotherapy. Fig. 3: Amino...
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Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issu 2020.10.29해당카페글 미리보기
as carbon dioxide. The lack of acute and chronic toxicity of citicoline has been repeatedly confirmed in rodents and dogs (see the most recent report by Schauss et al. [15] and the references quoted therein). An impressive example is the...
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Re: 암치료 효과를 증대시키는 Omega-3 Fatty Acids 2020.10.21해당카페글 미리보기
20-carbon fatty acids (EPA and AA) are cleaved from cell membrane phospholipids by phospholipase A2 and can be used to produce eicosanoids. Cyclooxygenase (COX) activity on EPA or AA results in the production of prostaglandins or...
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Re:Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outco 2020.10.20해당카페글 미리보기
SAH), which could be reversibly converted to Hcy via the enzyme SAH hydrolase. Finally, the activated DNMT enzyme will catalyze the transfer of a methyl group to carbon 5 of cytosines in the DNA to produce methylated DNA (mDNA). DNA...