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SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates t 2020.10.19해당카페글 미리보기
with expression vectors for the indicated protein. (C) ChIP experiments performed with a stable cell line containing both an integrated luciferase reporter and an integrated tetracycline-inducible GAL4-SirT3 fusion protein. The...
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Re: A Reappraisal of Thymosin Alpha1 in Cancer Therapy - 2019 리뷰 2020.10.10해당카페글 미리보기
1–thymopentin fusion peptide, in combination with Cy, reduced tumor weight more efficiently than Cy and Tα1, with or...Finally, the addition of an RGDR or iRGD motif at the C-terminus to favor tumor homing and cell internalization, or...
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Re: 독시사이클린의 항암효과 - 2017년 리뷰 2020.10.09해당카페글 미리보기
the cell cultures. We focused on MAM, which is a separate membrane compartment that connects the ER to mitochondria. Compared with monolayer cells, sphere-forming PC-3 cells showed higher levels of FACL4, a MAM marker protein (Fig. 3a...
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Re: Heat Shock Proteins in Cancer Immunotherapy 2020.10.09해당카페글 미리보기
human fusion protein vaccine composed of HSP70-HPV16 oE7 antigen was shown to elicit effective CD8+ antitumor cell-mediated response [50]. Another study by Abkin et al. showed that the purified HSP70-based gel diffused effectively...
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Mitohormesis - 2014 cell membrane 리뷰 2020.10.04해당카페글 미리보기
mitochondrial fusion and fission in physiology. Recent evidence suggests that tubular versus fragmented mitochondria...metabolic capacity, ROS production, and ability to induce cell death (Picard et al., 2013). Furthermore, other recent...
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Re: 신장암 옵디보-여보이(Ipilimumab in combination with nivolumab) 2018리뷰논문 2020.09.26해당카페글 미리보기
via fusion of mouse myeloma cells with spleen cells from a PD-1 receptor immunized Human Ig transgenic mouse...and transferred to a bioreactor for further large-scale cell culture. Nivolumab is purified using standard chromatography...
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60여개의 가수분해 효소를 가진 리소좀의 생리기능 - apoptosis, efferocytosis의 이해를 위해 2020.09.20해당카페글 미리보기
The fusion of lysosomes with the phagosome creates a phagolysosome; the pathogen is broken down by enzymes c. Waste material is expelled or assimilated (the latter not pictured) Parts: 1. Pathogens 2. Phagosome 3. Lysosomes 4. Waste...
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Re:Re:Efferocytosis at the Interface of Homeostasis and Pathology 2020.09.19해당카페글 미리보기
The fusion of lysosomes with the phagosome creates a phagolysosome; the pathogen is broken down by enzymes c. Waste material is expelled or assimilated (the latter not pictured) Parts: 1. Pathogens 2. Phagosome 3. Lysosomes 4. Waste...
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Re:The clearance of dying cells: table for two 2020.09.19해당카페글 미리보기
11C, which is inactivated by caspase-3 cleavage.36 Extracellularly exposed PtdSer is recognized by multiple, bona fide membrane receptors, such as T-cell immunoglobulin mucin receptor 4 (TIM4), brain-specific angiogenesis inhibitor 1...
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Re: 비타민 D의 말초신경회복 기전 2019년 review 2020.09.17해당카페글 미리보기
in C57B1/6 mice, previously treated with cuprizone, which induces oligodendrocyte apoptosis and subsequent myelin disruption. Calcitriol was able to promote the regenerative process by stimulating oligodendrocyte maturation and astrocyte...