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Re: The role of protein clearance mechanisms in organismal ageing and age-r 2022.10.09해당카페글 미리보기
autophagy (CMA)14,23,26,27. Macroautophagy (herein after called autophagy) is a self-catabolic process in which cytoplasm portions are engulfed into double membrane vesicles, which are named autophagosomes. About 35 genes, generically...
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Cellular Senescence in Brain Aging 2022.10.07해당카페글 미리보기
impairment of nuclear pores (nuclear pore “leakiness”) contributes to age-related changes in the nucleus and cytoplasm configuration (Schlachetzki et al., 2020). However, the brain is composed of thousands of different neural cell...
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senolytics, 세포 노화의 처리 2022.10.03해당카페글 미리보기
that produce high levels of reactive oxygen species (ROS). There is usually an enhanced level of lipofuscin in the cytoplasm and upregulation of p16 INK4a /p21 CIP1 in the nucleus. Biosynthesis and extracellular secretion of a large...
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Disea 2022.10.02해당카페글 미리보기
At physiological pH, O2•– is rapidly converted to peroxide (H2O2) with the help of superoxide dismutase in the cytoplasm and mitochondrial matrix (SOD1 and SOD2, respectively). Even though H2O2 is not actually a reactive radical, it is...
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Current understanding of metal ions in the pathogenesis of Alzheimer’s dise 2022.10.01해당카페글 미리보기
in accumulating iron and mediating the iron toxicities in the AD [96, 97]. Additionally, an increasing iron in the cytoplasm will saturate ferritin and thus prevent ferritin from entering the autolysosome which exacerbates iron...
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β-Hydroxybutyrate - 꼭 읽어야!! 2022.09.22해당카페글 미리보기
via a citrate shuttle mediated by citrate synthase inside mitochondria and ATP citrate lyase inside the cytoplasm (141). ATP citrate lyase is a key enzyme in fatty acid biosynthesis, but its role in facilitating acetyl-CoA export from...
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Re: Lysosome biology in autophagy .. 2020 논문 2022.09.20해당카페글 미리보기
in the intermembrane space of autolysosomes runs the risk of them damaging the membrane and leaking into the cytoplasm. The many layers of regulation set upon SNARE recruitment, SNARE complex formation, and lipid composition ensure that...
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Unification Thought - 11 - Methodology [The End] 2022.09.01해당카페글 미리보기
outer give-and-receive action. In living things, inner give-and-receive action occurs between the nucleus and the cytoplasm in each cell, while cells perform outer give-and-receive action with one another. In this way, in the...
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Unification Thought - 10 - Logic 2022.09.01해당카페글 미리보기
controls the strength properly. This kind of information is related to yang and yin. The cell has a nucleus and cytoplasm, and the nucleus controls the cytoplasm. The nucleus and cytoplasm are in the relationship of subject and object...
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Unification Thought - 2 - Ontology 2022.09.01해당카페글 미리보기
and students in schools, between the sun and the earth in the solar system, and between the nucleus and the cytoplasm in cells are neither relationships of Sungsang and Hyungsang nor relationships of yang and yin. These are relationships...