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Mitochondrial TCA cycle metabolites control physiology and disease 2024.02.15해당카페글 미리보기
promoted an increase in the 2-HG levels26. Noteworthy, fetal HSC kept their proliferative capacity in respiration-deficient conditions but were unable to differentiate. More recently, it has been reported that loss of mitochondrial...
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미토콘드리아 아미노산 합성, 대사.. 암.. 2024.02.15해당카페글 미리보기
in isocitrate dehydrogenase (IDH) wild-type (WT) GBM, and α-ketoglutarate (α-KG) mediates cell death in BCAT 1-deficient IDH WT GBM. This argument was supported by the combination of BCAT 1 inhibitor and α-KG induced tumor cell death...
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Re: The role of cell death in SARS-CoV-2 infection 2024.02.14해당카페글 미리보기
conditions and decreased in the recovery phase.122 In addition, numerous investigations have verified that GSH is deficient in severe COVID-19 patients.123,124 Because of GPX4 deficiency, GSH is unable to undergo peroxidation for...
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침입한 바이러스에 감염된 세포의 운명은? 2024.02.14해당카페글 미리보기
initialization is required to activate host defense against cytosolic bacteria and DNA viruses in Aim2-deficient mice. Among DNA viruses, the AIM2 inflammasome is activated in response to the vaccinia virus (VV) and MCMV. The VV induces...
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[서울대 소식] 보도자료 | 서울대학교 화학부 서필준 교수팀, 식물 캘러스 줄기세포의 전분화능을 낮추는 핵심 원인 규명 2024.02. 2024.02.10해당카페글 미리보기
TO APETALA 2.12 (RAP2.12) 단백질이 안정화되고, 해당 단백질은 SA 생합성 효소 유전자 SALICYLIC ACID INDUCTION DEFICIENT 2 (SID2) 프로모터에 직접 결합하여 캘러스 내 SA 축적을 유도한다. RAP2.12-SID2 모듈에 의한 SA 축적은 줄기세포 전분화능...
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Re: Autophagy in healthy aging and disease 2021년 nature review 2024.02.05해당카페글 미리보기
An inability to properly recycle amino acids through autophagy is linked to growth and developmental defects in Atg5-deficient mice and impaired growth during nitrogen starvation in several atg-deficient yeast cell lines (including atg1...
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Re: Cathepsin B in programmed cell death machinery 2024.02.02해당카페글 미리보기
for the loss of function of individual enzymes. CatZ regulates the acquired tumor-promoting functions of lesions deficient in both CatB and CatS as the compensatory protease [2]. However, double-knockout mice (CatB−/− CatL−/−) died...
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Re: 병든 세포의 제거와 수리, 리소좀 2024.02.02해당카페글 미리보기
세포 내 세포증인 대식세포증 경로를 통해 흡수된 세포 외 단백질의 리소좀 이화 작용을 억제합니다.46,47 When cells are deficient in nutrients, the inactivation of mTOR signaling and the formulation of the AMP-activated protein kinase (AMPK...
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Autophagy genes in biology and disease 2024.02.01해당카페글 미리보기
cerevisiae in the early 1990s fuelled rapid progress in the field, including the isolation of autophagy-deficient mutants, the identification of autophagy-related (ATG) genes and the characterization of related functional protein...
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'이 영양소' 부족, 몸에 염증 유발한다 2024.01.29해당카페글 미리보기
매우 높았다. 비타민D가 정상인 그룹은 CRP 수치가 평균 2.02mg/dL, '부족한'(insufficient) 그룹은 2.22mg/dL, '결핍된'(deficient) 그룹은 2.69 mg/dL이었다. 비타민D 수치가 충분하거나 부족한 그룹은 CRP 수치가 높을 가능성이 낮았다. 비타민D 수치가...