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Re: 암관련 섬유아세포가 암전이 과정의 기전과 치료법 2020.02.01해당카페글 미리보기
resistance Full size image Delivery of exosomal vesicles Besides the secretion of soluble factors, the release of exosomal vesicles is crucial to vehicle paracrine signals that drive cancer cell aggressiveness and therapy resistance...
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Re:Mitochondrial apoptosis: killing cancer using the enemy within 2020.01.29해당카페글 미리보기
slide Full size image Exploiting an addiction: drugging the BCL-2 family Most strategies to directly engage MOMP in cancer treatment have centred upon blocking anti-apoptotic BCL-2 function—the rationale being that this should either...
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Re:Mitochondrial uncoupling in cancer cells: Liabilities and opportunities 2020.01.18해당카페글 미리보기
e., coupling) between mitochondrial respiration and ATP synthesis, allowing separate regulation of bioenergetic and biosynthetic requirements while limiting superoxide generation. Consequently, UCPs may have a key role in the adaptive...
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Re:Mitochondrial Homeostasis and Cellular Senescence(세포 노화) 2020.01.17해당카페글 미리보기
a full senescent state. Of note, newly formed mitochondria in Ras-senescent cells were dysfunctional, with compromised ATP generation and increased ROS, due to the continuous oncogenic stress [162]. At variance with these findings, in...
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Re:Hypoxia and Selective Autophagy in Cancer Development and Therapy 2020.01.10해당카페글 미리보기
direct coupling of Drp1 with BNIP3-mediated mitophagy upon hypoxia is still missing. Furthermore, despite the fact that the involvement of PINK1/Parkin in hypoxia-induced mitophagy was initially excluded, latest evidence prompted...
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Re:Lysosomal Biology in Cancer 2020.01.10해당카페글 미리보기
for full activation of mTORC1. Loss of the tumor suppressor PTEN has been shown to activate mTORC1 via protein kinase B (AKT), which inhibits TSC1/TSC2 through phosphorylation [41]. TSC1/TSC2 can also be suppressed when LKB1 is...
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Re:Hallmarks of Cancer: The Next Generation 2020.01.05해당카페글 미리보기
Show full caption View Large Image Figure Viewer Download Hi-res image Download (PPT) Sustaining Proliferative Signaling Arguably the most fundamental trait of cancer cells involves their ability to sustain chronic proliferation. Normal...
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Re: 혈액뇌장벽(BBB)에 대하여 2020.01.01해당카페글 미리보기
neurovascular coupling enables astrocytes to relay signals that regulate blood flow in response to neuronal activity (Attwell et al. 2010; Gordon et al. 2011). This includes regulating the contraction/dilation of vascular smooth muscle...
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Re: 오래된 기침을 히스타민-브라디키닌 문제로 해결하는 법 2019.12.31해당카페글 미리보기
animals Full size image Discussion In this study we show, using a conscious guinea-pig model of cough, that centrally administered BK sensitizes the cough reflex via B2receptors. We also show that the central BK-induced sensitization...
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Re:Re: How cell death shapes cancer - nature review 논문 2019.12.29해당카페글 미리보기
Mechanisms coupling cell death and proliferation The discussed mouse models indicate that apoptotic cells promote cell divisions of neighboring cells, a process that can be termed death-driven proliferation, but the underlying signaling...