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Mitochondrial Fission, Fusion, and Stress 2020.04.08해당카페글 미리보기
and tRNAs might explain why mutations in tRNAs are much more common in human diseases than mutations in the integral protein components of the oxidative phosphorylation machinery. Also, protein aggregates may start to form immediately...
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Re:Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases 2020.03.25해당카페글 미리보기
BACE) and ϒ-secretase. ER stress sensors IRE1 and PERK are greatly influenced by presenilin protein, which is an integral membrane protein and a part of the ϒ-secretase complex, and is widely expressed in both ER and Golgi apparatus [96...
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Re:비타민 d와 c의 ER 스트레스 반응으로 인한 세포손상의 치료기전 2020.03.25해당카페글 미리보기
family death receptors activates caspase-8, which targets a limited number of substrates including Bap31, an integral membrane protein of the ER. The p20 caspase cleavage fragment of Bap31 can direct pro-apoptotic signals between the ER...
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Re:Re:알츠하이머의 원인인 아밀로이드 베타의 구조, 생리와 치료전략 2017 nature 리뷰 2020.03.22해당카페글 미리보기
in the amyloidogenic pathway The Aβ peptides are cleaved from the much larger precursor APP. APP is an integral membrane protein expressed in many tissues, especially in the synapses of neurons, which plays a central role in Alzheimer's...
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Re:Re:Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease 2020.03.22해당카페글 미리보기
the protein being neurotoxic or as a result of the loss of normal function. The work of recent studies indicate that the alpha-synuclein pathogenic species spreads through the nervous system by inducing aggregation of alpha-synuclein in...
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Re:프로바이오틱스의 항암효과 2019년 리뷰논문 2020.03.11해당카페글 미리보기
death protein 1 (PD1) or programmed death-ligand 1 (PD-L1) targets] (77,78). In particular, Routy et al (74) observed that patients with melanoma treated with antibiotics along with the anti-PD1/anti-PD-L1 immunotherapy had a lower...
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세포막의 구조와 기능에 대한 탐구!! 2020.03.02해당카페글 미리보기
of the cerebroside that has myristic acid as its fatty acid and galactose as its sugar. Distinguish between an integral protein and a peripheral protein. What is one key function of integral proteins? Answers phospholipid sphingolipid...
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Re:The Curious Chemical Biology of Cytosine: Deamination, Methylation and Oxidation as Modulators of Genomic Potential 2020.02.25해당카페글 미리보기
an integral role in biology. In the conventional view, the genome is a long polymer of A, C, G and T, which together define and differentiate organisms. However, it is increasingly clear that diversity within an organism is often...
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Re:Re:Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline 2020.02.19해당카페글 미리보기
G protein signaling and/or changes in Ca signaling networks. Although the multiplicity of potential mechanisms and the complexity of cholinergic signaling may be inconvenient to study, the data are, in fact, consistent with multiple...
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Re:Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases 2020.02.16해당카페글 미리보기
Google Scholar] [15] Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S.. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123:1777-88; PMID:8276896; http://dx.doi.org/10.1083/jcb...