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면역세포의 노화. 2023년 nature review 2024.07.06해당카페글 미리보기
ATM-related DNA damage, induces extracellular regulated protein kinases 1/2 (ERK1/2) and p38 pathways, and activates signal transducer and activator of transcription 1/3 (STAT1/3) with upregulation of p21-p16-p53, eventually causing T...
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Re: T 세포로 보는 자가면역으로 전환하는 시점 탐구!! 2023년 Nature 2024.07.06해당카페글 미리보기
of GATA-3, IRF4 and BATF to promote IL-9 transcription and Th9 cell development.99,100 Besides, TGF-β signaling activates Smads (Smad2/3), PU.1 and IRF8, contributing to Th9 cell differentiation.99,100 Furthermore, IRF4, PU.1, IRF8, and...
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스트레스 반응이 어떻게 자가면역 쇼그렌증후군을 일으키는가? 2024.07.05해당카페글 미리보기
also characterized by the derangement of the responses of ANS to stressors. In response to mild stressors the ANS activates the sympathetic system, which is accompanied by a reciprocal decrease in parasympathetic tone. When the...
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71. The heart of the Lord waiting for the number to be filled, the power to 2024.07.05해당카페글 미리보기
is fulfilled. The reason why the number is fulfilled for a short period of time is because the work of force that activates the force that makes their wishes come true.(Rev.7:3, 11:3). In other words, it is the same as what is said in...
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Re: 쇼그렌 증후군 최신약물 탐구 노력의 실패!! 2024.07.05해당카페글 미리보기
mediated pyroptosis in exocrine glands [Citation29]. Massive circulating cell-free DNA (cf-DNA) accumulation activates inflammasome [Citation30], leading to activated caspase-1, causing elevated pro-inflammatory cytokines, and resulting...
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만성염증 --> 자가면역 염증으로 진행하는 과정의 중요 인자 NF-κB 탐구!! 2024.07.04해당카페글 미리보기
RANKL 신호는 NF-κB의 활성화와 LTα1β2의 추가 상향 조절로 이어집니다. Signaling through TNFR1, LTβR, and RANK activates p65-containing complexes and, hence, it is not surprising that rela−/−/tnfr1−/− double-knockout mice lack Peyer...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
B2 precursor protein, p100.3,11 A central signaling molecule for this pathway is NF-κB-inducing kinase (NIK), which activates and functionally cooperates with IKKα to mediate p100 phosphorylation, which in turn induces p100...
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Crosstalk of reactive oxygen species and NF-κB signaling 2024.07.04해당카페글 미리보기
A, Zhang W, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008; 9:1364–1370. Article CAS PubMed PubMed Central...
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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
primarily activated by BCR, TCR, TLR, IL-1R, and TNFR. BCR and TCR initiate a multistage enzymatic reaction that activates the CARMA1/BCL-10/MALT1 complex. TLR, IL-1R, and TNFR primarily promote activation of the TAK1/TAB complex...
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Re: 통풍, 요산을 대신하는 항산화제!! 2024.07.02해당카페글 미리보기
nutrient with scavenging activity. It binds directly to the superoxide anion and hydroxyl radicals and de-activates them. It is known from epidemiological studies that one of the first lifestyle changes suggested for hyperuricemic...