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Re: T 세포로 보는 자가면역으로 전환하는 시점 탐구!! 2023년 Nature 2024.07.06해당카페글 미리보기
rearrangement and then form a fully functional αβTCR on the surface, which recognizes MHC I- or MHC II-peptide complexes presented by thymic APCs to become either CD8+ SP or CD4+ SP thymocytes.8 On one hand, the interaction of peptide...
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Re: 쇼그렌 증후군 최신약물 탐구 노력의 실패!! 2024.07.05해당카페글 미리보기
Type I IFN induces B cell activation and autoantibody production, which in turn leads to the formation of immune complexes and promotes escalated type I IFN production [Citation23]. The inflammasome pathway is normally induced under...
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Re: 안구건조, 입마름 쇼그렌 증후군 jama 논문 탐구 2024.07.04해당카페글 미리보기
SS. These autoantibodies include rheumatoid factors, antinuclear antibodies, and antibodies to the small RNA-protein complexes Ro/SS-A and La/SS-B. These autoantibodies may contribute to tissue dysfunction before inflammation is evident...
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만성염증 --> 자가면역 염증으로 진행하는 과정의 중요 인자 NF-κB 탐구!! 2024.07.04해당카페글 미리보기
schematics of canonical and non-canonical NF-κB pathways are shown. In the canonical pathway NEMO-containing IKK complexes are activated and induce phosphorylation and degradation of IκBα leading to the release of NF-κB dimers...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
and function. NF-κB in inflammasome regulation Inflammasomes are a group of intracellular multi-protein complexes assembled in response to PAMPs and DAMPs, and characterized by the activation of inflammatory caspases.21 Canonical...
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Crosstalk of reactive oxygen species and NF-κB signaling 2024.07.04해당카페글 미리보기
1 Intracellular Sources of ROS. The mitochondria are a major source of ROS, especially through electron leakage from Complexes I and III. ROS are also produced by NAD(P)H oxidases, sometimes in response to cytokines and other growth...
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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
lymphotoxin alpha, LTB lymphotoxin beta, LT-βR lymphotoxin beta receptor, LUBAC linear ubiquitin chain assembly complexes, LYN LYN proto-oncogene, Src family tyrosine kinase, MALT1 MALT1 paracaspase, MHC major histocompatibility complex...
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Re: 활성산소(산화물질)을 생성하는 기관은? 미토콘드리아, 페록시좀 2024.07.03해당카페글 미리보기
DLD), a common subunit of the α-ketoglutarate dehydrogenase and pyruvate dehydrogenase multi-enzyme complexes, in the mitochondrial matrix (Andreyev et al., 2005; Circu and Aw, 2010), and (iii) monoamine oxidase, a mitochondrial outer...
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Journal de 12h30 du mardi 2 juillet 2024 2024.07.02해당카페글 미리보기
sur les réseaux sociaux. L'invité de la rédaction : David Chavalarias, directeur de l'Institut des Systèmes Complexes et chercheur à l'EHESS. Les autres titres de l'actualité C'est probablement l'autre exemple le plus manifeste...
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Re: B 세포 교차반응 자가면역 질환들 RA, SLE, MS, 당뇨... 2024.06.30해당카페글 미리보기
Genetic dysfunction associated with T cell receptors (TCRs), immunoglobulins (Igs) and major histocompatibility complexes (MHCs), are most commonly linked to autoimmune diseases, whereas reported environmental factors among others...