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만성염증 --> 자가면역 염증으로 진행하는 과정의 중요 인자 NF-κB 탐구!! 2024.07.04해당카페글 미리보기
세린 및 트레오닌 풍부 영역. ) In most cells, NF-κB complexes are inactive, residing predominantly in the cytoplasm in a complex with inhibitory IκB proteins (IκBα, IκBβ, IκBɛ, IκBζ, p100, p105, Bcl3, IκBns; Figure 1). When...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
DNA element, κB enhancer, as various hetero- or homo-dimers.2 The NF-κB proteins are normally sequestered in the cytoplasm by a family of inhibitory proteins, including IκB family members and related proteins characterized by the...
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Crosstalk of reactive oxygen species and NF-κB signaling 2024.07.04해당카페글 미리보기
They also serve as hydrogen donors to the thioredoxin-dependent peroxide reductases. Trx1 is expressed in the cytoplasm and nucleus. Inactivation of Trx1 in mice also results in early embryonic lethality 50. Trx2 is localized within the...
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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
of the NF-κB transcription factor family can form homo- or heterodimers, which bind to IκB and sequester in the cytoplasm in an inactive form, with p65/p50 being the most common dimerization form.6 Specific functions of several NF-κB...
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Re: 활성산소(산화물질)을 생성하는 기관은? 미토콘드리아, 페록시좀 2024.07.03해당카페글 미리보기
reducing equivalents without physical exchange of these redox cofactors between the lumen of the organelle and the cytoplasm (Rottensteiner and Theodoulou, 2006; Antonenkov et al., 2010; Schueren et al., 2014)—it is also not yet clear...
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주로 지질, 단백질, DNA를 파괴하는 활성산소 탐구!! 2024.07.03해당카페글 미리보기
in all other mammals and most chordates), three forms of superoxide dismutase are present. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. The first is a dimer (consists of two units), while the...
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안구건조, 입마름 쇼그렌 증후군 탐구!! 2024.06.28해당카페글 미리보기
cells12. The SSA/Ro antigen comprises two ribonucleoproteins, Ro52 and Ro60, which are both present in the cytoplasm of all mammalian cells. Although a direct contribution of autoantibodies to exocrine gland dysfunction in humans has not...
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밀, 보리(글루텐) 만성염증, 자가면역 염증 과정 최신 논문... 2024.06.26해당카페글 미리보기
of a GFD [76]. In a moderate percentage of adult CD patients, a blood smear can detect changes in the membrane and cytoplasm of red blood cells (i.e., Howell–Jolly bodies), whereas pitted red cells can be identified by Nomarski phase...
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땀에 관한 탐구!! 2024.06.25해당카페글 미리보기
and Na-K-ATPase activity [5]. The dark cells are distinguishable by the abundance of dark cell granules in the cytoplasm. Their function is poorly understood, but thought to potentially act as a repository for various bioactive materials...
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비타민 d 생성하는 각질형성세포.. 건선 치료탐구중.. 2024.06.24해당카페글 미리보기
factors Gli1, Gli2, and Gli3. Suppressor of fused (Sufu) may maintain these transcription factors in the cytoplasm and/or limit their activity in the nucleus such that the loss of Sufu leads to increased Hh signaling [130, 134]. However...