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Re: T 세포로 보는 자가면역으로 전환하는 시점 탐구!! 2023년 Nature 2024.07.06해당카페글 미리보기
are required for Bcl11b activation.17,18,19 GATA-3 suppresses both B cell and myeloid cell differentiation in TCF-1-deficient ETPs,15 whereas Bcl11b restricts the progenitor differentiation into innate lymphoid and myeloid lineages.20,21...
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만성염증 --> 자가면역으로 전환하는 시점 탐구!! 2024.07.06해당카페글 미리보기
7,8], although this needs to be more definitively assessed. When naturally occurring Tregs are absent in Foxp3-deficient islet antigen-specific BDC2.5 TCR transgenic NOD mice, disease onset is significantly earlier [7]. Interestingly...
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스트레스 반응이 어떻게 자가면역 쇼그렌증후군을 일으키는가? 2024.07.05해당카페글 미리보기
as a whole may fail to reset to the normal level of function, and remains ‘tuned’ to excess sympathetic and deficient parasympathetic activation and the ANS does not reset to baseline status. This state may persist indefinitely, giving...
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만성염증 --> 자가면역 염증으로 진행하는 과정의 중요 인자 NF-κB 탐구!! 2024.07.04해당카페글 미리보기
of most secondary lymphoid organs (Figure 2). However, the non-canonical pathway, as assessed by examining mice deficient for IKKα, p52, NIK, or RelB, is especially important both during organogenesis and for maintenance of splenic...
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Swan wrangling and ‘steamy trysts’ 2024.07.04해당카페글 미리보기
no pomp, there’s no point, surely? Duchy Original oaten biscuits and broad bean coronation quiche are tragically deficient in the shock, awe and fabulousness department compared with George IV’s 100-course banquets on a 4,000-piece...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
of IL-21, a γc family cytokine important for the differentiation Th17 and Tfh cells.45 Consistently, the c-Rel-deficient mice have a defect in both Th17 and Tfh responses.45 Regulatory T (Treg) cells, generated along with thymocyte...
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Crosstalk of reactive oxygen species and NF-κB signaling 2024.07.04해당카페글 미리보기
target in at least one study 44. It catalyzes a similar reaction, causing the dismutation of .O2− into H2O2. SOD1-deficient mice have a shortened life span, have persistent oxidative damage and develop hepatocellular carcinoma 45...
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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
CK1alpha) complex phosphorylates and inactivates β-catenin. NF-κB transcriptional activation is decreased in GSK3-deficient embryonic fibroblasts without affecting IκB degradation and nuclear translocation of NF-κB.150 Disheveled...
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Re: 활성산소(산화물질)을 생성하는 기관은? 미토콘드리아, 페록시좀 2024.07.03해당카페글 미리보기
et al., 2002), whereas the protective actions are gone in cells lacking plasmalogens. Photosensitisized plasmalogen-deficient CHO cells and mouse embryonic fibroblasts are hypersensitive to light treatment (Zoeller et al., 1988; Wang et...
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Topic for July. 5. ( Fri ) 2024.07.01해당카페글 미리보기
reason, they become obsessively obsessed with it, and because they are not receiving proper nutrition, they become deficient in serotonin (a neurotransmitter that contributes to regulating body temperature, memory, emotions, sleep...