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Re: 만성염증 자가면역 염증 전환 지점 탐구.. 자가반응 T 세포... 2024.07.08해당카페글 미리보기
to downregulate the ongoing inflammation through increased presence of Tregs, but these are unable to effectively inhibit the disease. As outlined in the introduction, there are at least four mechanisms of rendering Tregs dysfunctional...
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면역세포의 노화. 2023년 nature review 2024.07.06해당카페글 미리보기
T (Treg) cells is increased in the TME,63 and hypoxia-driven accumulation of cyclic adenosine monophosphate can inhibit tumor-specific effector T cells, activating p38 pathways.64,65,66,67 Mechanistically, competition for glucose between...
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만성염증 --> 자가면역으로 전환하는 시점 탐구!! 2024.07.06해당카페글 미리보기
Go to: Why do Tregs fail to suppress during autoimmune disease? Under normal conditions, Tregs effectively inhibit excessive inflammation and autoimmune manifestations [6]. However, in autoimmune diseases Tregs fail to control the...
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Re: 안구건조, 입마름 쇼그렌 증후군 jama 논문 탐구 2024.07.04해당카페글 미리보기
1.5 L of saliva daily. Saliva contains lysozyme, lactoferrin, lactoperoxidase, and histidine-rich polypeptides, which inhibit bacteria and fungi.46,47 Furthermore, salivary glycoproteins are thought to play a role in inhibition of...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
p105 and its processing product p50, have also been associated with IBD.98–100 These genetic alterations appear to inhibit NFKB1 gene expression or alter the stability and function of the protein products. Consistently, mice carrying a...
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Crosstalk of reactive oxygen species and NF-κB signaling 2024.07.04해당카페글 미리보기
NF-κB proteins are synthesized as larger p105 and p100 precursor proteins, which have C-terminal ankyrin repeats that inhibit DNA binding until partially processed by proteasome to the smaller p50 and p52 products, respectively 1, 2, 3...
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Re: NF-κB 탐구!! NF-κB in biology and targeted therapy 2024 네이처 논문 2024.07.04해당카페글 미리보기
β-transducin repeats-containing proteins (β-TrCP) ubiquitin ligase and the 26 S proteasome.8 p100 also functions to inhibit RelB nuclear translocation.83,86 Non-canonical NF-κB signaling activated by receptors such as CD40, B...
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주로 지질, 단백질, DNA를 파괴하는 활성산소 탐구!! 2024.07.03해당카페글 미리보기
in DNA, and blocking micro cell line formation.[22] Hence vitamin E may be useful in cancer prevention and inhibit carcinogenesis by the stimulation of the immune system. The administration of a mixture of the above three antioxidant...
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음식 이상반응에서 알레르기 교차반응 epitope 탐구!! 2024.06.30해당카페글 미리보기
reactivity including inhibition assays and histamine release assays to confirm the ability of these epitopes to inhibit IgE and activate effector cells. In birch-endemic regions, soybean allergy is based on cross-reactivity between birch...
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Re: B 세포와 자가면역 2024.06.28해당카페글 미리보기
independent pathogenic functions. Secreted autoantibodies specific to receptors or receptor ligands can activate or inhibit receptor functions. Deposited immune complexes can activate complement and effector cells. Autoantibodies can...