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Re: 음식치료제 : 베타 하이드로뷰티레이트.. 항염증 효과 탐구!! 2024.07.17해당카페글 미리보기
transition pore, which maintains the electrochemical potential gradient required for ATP generation of oxidative phosphorylation (56). This closure was thought to protect neurons against ROS-induced apoptosis (90, 91) (Figure 2F...
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Re: Re: 활성산소의 지질(lipid) 손상에 대한 탐구!! 2024.07.16해당카페글 미리보기
transition pore and proapoptotic proteins into cytoplasm by interacting with apoptotic protease-activating factor 1 (Apaf-1) and procaspase-9 to constitute apoptosome [56, 57]. An assembly of apoptosome leads to caspase-9 activation...
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Re: 자가포식-리소좀 시스템 2020 nature 논문 . 2024.07.10해당카페글 미리보기
the nuclear translocation of the transcription factor EB (TFEB), which governs the transcription levels of lysosomal and autophagy genes5,6,7. Conversely, starvation causes mTORC1 to dissociate from lysosomes, leading to the induction of...
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Re: 염증유발 과정에서 NF-κB signaling 탐구 .. 2024.07.04해당카페글 미리보기
as pore-forming toxins, viral RNAs, ATP and crystalline substances.60,64 These diverse stimuli are thought to activate NLRP3 via inducing different cellular events, including K+ efflux, Ca2+ signaling, mitochondrial and lysosomal damages...
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Re: The role of cell death in SARS-CoV-2 infection 2024.02.14해당카페글 미리보기
and nuclear accumulation of IRF3 and STAT1, which activates TNF-α secretion and results in cellular apoptosis through the TNFR1 pathway. SARS-CoV-2 ORF7a recruits Bcl-XL to the ER, activating the cellular ER stress response and...
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침입한 바이러스에 감염된 세포의 운명은? 2024.02.14해당카페글 미리보기
shrinkage, nuclear condensation, bleb formation, and retained membrane integrity 모두 삼투압 불균형으로 인한 세포질 부종과 괴사 및 발열성 세포사에서의 초기 막 손상의 징후입니다. 카스파제 주도의 세포 사멸은 많은 상황에서 항염증제로 간주...
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Re: Autophagy in healthy aging and disease 2021년 nature review 2024.02.05해당카페글 미리보기
the nuclear export protein exportin-1 (XPO-1) enhances autophagy by enrichment of HLH-30 in the nucleus, which is accompanied by proteostatic benefits and improved longevity47. Moreover, rapamycin, an inhibitor of the mTOR pathway, has...
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Re: Role of immune cells in the removal of deleterious senescent cells 2024.02.05해당카페글 미리보기
large-pore pannexin 1 channels (which can conduct molecules up to 1 kDa). Three aspects of metabolite release from apoptotic cells are particularly interesting from a therapeutic standpoint. First, apoptotic cells are not simply emptying...
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Re: Cathepsin B in programmed cell death machinery 2024.02.02해당카페글 미리보기
Bak pore formation, either by directly activating Bax/Bak or passively by sequestering the anti-apoptotic Bcl-2 proteins. Once active Bax/Bak have induced mitochondrial outer membrane permeabilization, pro-apoptotic factors such as...
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Re: Transit Amplifying Cells (TACs): a still not fully understood cell popu 2023.11.06해당카페글 미리보기
the nuclear transcription factor Myc and is involved in the transformation of hair follicle SCs to TACs (Shen et al., 2017). Using hair follicles as paradigm, Hsu, Li and Fuchs also showed that while primed SCs generate TACs, quiescent...